PDE1B (phosphodiesterase 1B)

2014-11-01  

Identity

HGNC
LOCATION
12q13.2
LOCUSID
ALIAS
HEL-S-79p,PDE1B1,PDES1B

Other Information

Locus ID:

NCBI: 5153
MIM: 171891
HGNC: 8775
Ensembl: ENSG00000123360

Variants:

dbSNP: 5153
ClinVar: 5153
TCGA: ENSG00000123360
COSMIC: PDE1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123360ENST00000243052Q01064
ENSG00000123360ENST00000243052A0A024RB59
ENSG00000123360ENST00000538346B4DK72
ENSG00000123360ENST00000550285F8VZK3
ENSG00000123360ENST00000550620Q01064
ENSG00000123360ENST00000611899A0A087WTW8

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Calcium signaling pathwayKEGGko04020
Olfactory transductionKEGGko04740
Taste transductionKEGGko04742
Purine metabolismKEGGhsa00230
Calcium signaling pathwayKEGGhsa04020
Olfactory transductionKEGGhsa04740
Taste transductionKEGGhsa04742
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
DAG and IP3 signalingREACTOMER-HSA-1489509
CaM pathwayREACTOMER-HSA-111997
Calmodulin induced eventsREACTOMER-HSA-111933
Cam-PDE 1 activationREACTOMER-HSA-111957
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Nitric oxide stimulates guanylate cyclaseREACTOMER-HSA-392154
cGMP effectsREACTOMER-HSA-418457
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
EGFR interacts with phospholipase C-gammaREACTOMER-HSA-212718
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
PLC-gamma1 signallingREACTOMER-HSA-167021
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
Opioid SignallingREACTOMER-HSA-111885
G-protein mediated eventsREACTOMER-HSA-112040
PLC beta mediated eventsREACTOMER-HSA-112043
Ca-dependent eventsREACTOMER-HSA-111996

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
156251042005Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation.18
164071682006PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte.11
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
282824902017Gene Augmentation Therapy for a Missense Substitution in the cGMP-Binding Domain of Ovine CNGA3 Gene Restores Vision in Day-Blind Sheep.5

Citation

Dessen P

PDE1B (phosphodiesterase 1B)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71791/pde1b