PDE2A (phosphodiesterase 2A)

2011-10-01 Affiliation

Identity

HGNC

PDE2A

LOCATION

11q13.4

LOCUSID

5138

ALIAS

CGS-PDE,IDDPADS,PDE2A1,PED2A4,cGSPDE

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5138
MIM: 602658
HGNC: 8777
Ensembl: ENSG00000186642

Variants:

dbSNP: 5138
ClinVar: 5138
TCGA: ENSG00000186642
COSMIC: PDE2A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000186642	ENST00000334456	O00408
ENSG00000186642	ENST00000376450	O00408
ENSG00000186642	ENST00000418754	E9PEF1
ENSG00000186642	ENST00000420501	C9JPD5
ENSG00000186642	ENST00000441209	H7C009
ENSG00000186642	ENST00000444035	O00408
ENSG00000186642	ENST00000475807	H0YFL1
ENSG00000186642	ENST00000535701	F5H2V7
ENSG00000186642	ENST00000536308	F5H3Z7
ENSG00000186642	ENST00000536458	F5H1D7
ENSG00000186642	ENST00000537631	H0YGL2
ENSG00000186642	ENST00000538299	H0YG13
ENSG00000186642	ENST00000538749	F5H130
ENSG00000186642	ENST00000539367	F5H2R8
ENSG00000186642	ENST00000540345	O00408
ENSG00000186642	ENST00000541998	F5H2R8
ENSG00000186642	ENST00000542223	F5GXX2
ENSG00000186642	ENST00000542969	F5H5P8
ENSG00000186642	ENST00000543575	F5H2R8
ENSG00000186642	ENST00000543750	F5H143
ENSG00000186642	ENST00000544570	O00408
ENSG00000186642	ENST00000546038	F5H2Z0

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Purine metabolism	KEGG	ko00230
Olfactory transduction	KEGG	ko04740
Purine metabolism	KEGG	hsa00230
Olfactory transduction	KEGG	hsa04740
Morphine addiction	KEGG	hsa05032
Morphine addiction	KEGG	ko05032
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
cGMP signaling	KEGG	hsa_M00694
cGMP signaling	KEGG	M00694
Hemostasis	REACTOME	R-HSA-109582
Platelet homeostasis	REACTOME	R-HSA-418346
Nitric oxide stimulates guanylate cyclase	REACTOME	R-HSA-392154
cGMP effects	REACTOME	R-HSA-418457
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555
Aldosterone synthesis and secretion	KEGG	hsa04925
Aldosterone synthesis and secretion	KEGG	ko04925

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20351714	2011	Poor replication of candidate genes for major depressive disorder using genome-wide association data.	92
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
26095046	2015	Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy.	63
19828435	2009	Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct.	50
21724846	2011	A phosphodiesterase 2A isoform localized to mitochondria regulates respiration.	34
19390057	2009	Phosphodiesterase 2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1 and NADPH oxidase 2.	32
15650061	2005	Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability.	31
23810893	2013	Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes.	31
25230992	2015	Tumour growth inhibition and anti-angiogenic effects using curcumin correspond to combined PDE2 and PDE4 inhibition.	13
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11

Citation

Dessen P

PDE2A (phosphodiesterase 2A)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52455/pde2a