PDE4A (phosphodiesterase 4A)

2007-02-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
DPDE2,PDE4,PDE46
FUSION GENES

Other Information

Locus ID:

NCBI: 5141
MIM: 600126
HGNC: 8780
Ensembl: ENSG00000065989

Variants:

dbSNP: 5141
ClinVar: 5141
TCGA: ENSG00000065989
COSMIC: PDE4A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000065989ENST00000293683P27815
ENSG00000065989ENST00000344979P27815
ENSG00000065989ENST00000380702P27815
ENSG00000065989ENST00000440014P27815
ENSG00000065989ENST00000589073K7EKV1
ENSG00000065989ENST00000591971K7ENX7
ENSG00000065989ENST00000592685P27815

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Purine metabolismKEGGhsa00230
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
Opioid SignallingREACTOMER-HSA-111885
DARPP-32 eventsREACTOMER-HSA-180024

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA59ARRB1GenePathwayassociated
PA60ARRB2GenePathwayassociated

References

Pubmed IDYearTitleCitations
162573732005Keynote review: phosphodiesterase-4 as a therapeutic target.158
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
175768032007p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway.46
211612472011Conserved expression and functions of PDE4 in rodent and human heart.43
190470982008Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression.42
128107162003Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2.37
119942732002TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid.29
150475692004Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers.27
201930792010The inhaled phosphodiesterase 4 inhibitor GSK256066 reduces allergen challenge responses in asthma.27
200860952010Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex.26

Citation

Dessen P

PDE4A (phosphodiesterase 4A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45808/pde4a