PDE4B (phosphodiesterase 4B)

2007-02-01 Affiliation

Identity

HGNC

PDE4B

LOCATION

1p31.3

LOCUSID

5142

ALIAS

DPDE4,PDEIVB

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5142
MIM: 600127
HGNC: 8781
Ensembl: ENSG00000184588

Variants:

dbSNP: 5142
ClinVar: 5142
TCGA: ENSG00000184588
COSMIC: PDE4B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000184588	ENST00000329654	Q07343
ENSG00000184588	ENST00000329654	X5DNX5
ENSG00000184588	ENST00000341517	Q07343
ENSG00000184588	ENST00000341517	X5DNX5
ENSG00000184588	ENST00000371045	Q07343
ENSG00000184588	ENST00000412480	E9PMG3
ENSG00000184588	ENST00000423207	Q07343
ENSG00000184588	ENST00000480109	Q07343
ENSG00000184588	ENST00000491340	H0YCV7
ENSG00000184588	ENST00000526197	E9PR34
ENSG00000184588	ENST00000528771	E9PJ03
ENSG00000184588	ENST00000531025	E9PNB0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Purine metabolism	KEGG	ko00230
Purine metabolism	KEGG	hsa00230
Morphine addiction	KEGG	hsa05032
Morphine addiction	KEGG	ko05032
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555
Opioid Signalling	REACTOME	R-HSA-111885
DARPP-32 events	REACTOME	R-HSA-180024

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA443309	Alcoholism	Disease	ClinicalAnnotation	associated	PD	32451486
PA448073	ethanol	Chemical	ClinicalAnnotation	associated	PD	32451486
PA59	ARRB1	Gene	Pathway	associated
PA60	ARRB2	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
16293762	2005	DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.	220
17481393	2007	Behavioral phenotypes of Disc1 missense mutations in mice.	194
17088426	2006	PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.	86
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19240061	2009	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	75
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
20201926	2010	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	45
15331441	2005	The phosphodiesterase PDE4B limits cAMP-associated PI3K/AKT-dependent apoptosis in diffuse large B-cell lymphoma.	44
18983980	2008	DISC1, PDE4B, and NDE1 at the centrosome and synapse.	44
18394866	2008	PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia.	43

Citation

Dessen P

PDE4B (phosphodiesterase 4B)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46230/pde4b