| Nomenclature |
HGNC (Hugo) | PDE6B 8786 |
| Cards |
Entrez_Gene (NCBI) | PDE6B 5158 phosphodiesterase 6B |
Aliases | CSNB3; CSNBAD2; GMP-PDEbeta; PDEB; |
| RP40; rd1 |
GeneCards (Weizmann) | PDE6B |
Ensembl hg19 (Hinxton) | ENSG00000133256 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000133256 [Gene_View]  ENSG00000133256 [Sequence] chr4:625574-670892 [Contig_View] PDE6B [Vega] |
ICGC DataPortal | ENSG00000133256 |
TCGA cBioPortal | PDE6B |
AceView (NCBI) | PDE6B |
Genatlas (Paris) | PDE6B |
WikiGenes | 5158 |
SOURCE (Princeton) | PDE6B |
Genetics Home Reference (NIH) | PDE6B |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | PDE6B - chr4:625574-670892 + 4p16.3 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | PDE6B - 4p16.3 [Description] (hg19-Feb_2009) |
GoldenPath | PDE6B - 4p16.3 [CytoView hg19] PDE6B - 4p16.3 [CytoView hg38] |
ImmunoBase | ENSG00000133256 |
Mapping of homologs : NCBI | PDE6B [Mapview hg19] PDE6B [Mapview hg38] |
OMIM | 163500 180072 613801 |
| Gene and transcription |
Genbank (Entrez) | AI131517 AK295285 AK308789 AK309252 AK316054 |
RefSeq transcript (Entrez) | NM_000283 NM_001145291 NM_001145292 NM_001350154 NM_001350155 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | PDE6B |
Cluster EST : Unigene | Hs.654544 [ NCBI ] |
CGAP (NCI) | Hs.654544 |
Alternative Splicing Gallery | ENSG00000133256 |
Gene Expression | PDE6B [ NCBI-GEO ] PDE6B [ EBI - ARRAY_EXPRESS ]
PDE6B [ SEEK ] PDE6B [ MEM ] |
Gene Expression Viewer (FireBrowse) | PDE6B [ Firebrowse - Broad ] |
SOURCE (Princeton) | Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60] |
Genevestigator | Expression in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 5158 |
GTEX Portal (Tissue expression) | PDE6B |
Human Protein Atlas | ENSG00000133256-PDE6B [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | P35913 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | P35913 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | P35913 |
Splice isoforms : SwissVar | P35913 |
Catalytic activity : Enzyme | 3.1.4.17 [ Enzyme-Expasy ] 3.1.4.173.1.4.17 [ IntEnz-EBI ] 3.1.4.17 [ BRENDA ] 3.1.4.17 [ KEGG ] |
PhosPhoSitePlus | P35913 |
Domaine pattern : Prosite (Expaxy) | PDEASE_I_1 (PS00126) PDEASE_I_2 (PS51845) |
Domains : Interpro (EBI) | GAF GAF-like_dom_sf HD/PDEase_dom PDEase PDEase_catalytic_dom PDEase_catalytic_dom_sf PDEase_CS |
Domain families : Pfam (Sanger) | GAF (PF01590) PDEase_I (PF00233) |
Domain families : Pfam (NCBI) | pfam01590 pfam00233 |
Domain families : Smart (EMBL) | GAF (SM00065) HDc (SM00471) |
Conserved Domain (NCBI) | PDE6B |
DMDM Disease mutations | 5158 |
Blocks (Seattle) | PDE6B |
Superfamily | P35913 |
Human Protein Atlas [tissue] | ENSG00000133256-PDE6B [tissue] |
Peptide Atlas | P35913 |
HPRD | 01571 |
IPI | IPI00784027 IPI00922666 IPI00747657 IPI00921912 IPI00946197 IPI00946579 IPI00945707 IPI00945720 IPI00945175 |
| Protein Interaction databases |
DIP (DOE-UCLA) | P35913 |
IntAct (EBI) | P35913 |
FunCoup | ENSG00000133256 |
BioGRID | PDE6B |
STRING (EMBL) | PDE6B |
ZODIAC | PDE6B |
| Ontologies - Pathways |
QuickGO | P35913 |
Ontology : AmiGO | plasma membrane G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway Wnt signaling pathway, calcium modulating pathway visual perception phototransduction, visible light rhodopsin mediated signaling pathway regulation of rhodopsin mediated signaling pathway metal ion binding 3',5'-cyclic-GMP phosphodiesterase activity 3',5'-cyclic-GMP phosphodiesterase activity regulation of cytosolic calcium ion concentration regulation of cytosolic calcium ion concentration retina development in camera-type eye photoreceptor disc membrane |
Ontology : EGO-EBI | plasma membrane G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway Wnt signaling pathway, calcium modulating pathway visual perception phototransduction, visible light rhodopsin mediated signaling pathway regulation of rhodopsin mediated signaling pathway metal ion binding 3',5'-cyclic-GMP phosphodiesterase activity 3',5'-cyclic-GMP phosphodiesterase activity regulation of cytosolic calcium ion concentration regulation of cytosolic calcium ion concentration retina development in camera-type eye photoreceptor disc membrane |
Pathways : BIOCARTA | Visual Signal Transduction [Genes] |
NDEx Network | PDE6B |
Atlas of Cancer Signalling Network | PDE6B |
Wikipedia pathways | PDE6B |
| Orthology - Evolution |
OrthoDB | 5158 |
GeneTree (enSembl) | ENSG00000133256 |
Phylogenetic Trees/Animal Genes : TreeFam | PDE6B |
HOGENOM | P35913 |
Homologs : HomoloGene | PDE6B |
Homology/Alignments : Family Browser (UCSC) | PDE6B |
| Gene fusions - Rearrangements |
Fusion : Quiver | PDE6B |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | PDE6B [hg38] |
dbSNP Single Nucleotide Polymorphism (NCBI) | PDE6B |
dbVar | PDE6B |
ClinVar | PDE6B |
1000_Genomes | PDE6B |
Exome Variant Server | PDE6B |
ExAC (Exome Aggregation Consortium) | ENSG00000133256 |
GNOMAD Browser | ENSG00000133256 |
Varsome Browser | PDE6B |
Genetic variants : HAPMAP | 5158 |
Genomic Variants (DGV) | PDE6B [DGVbeta] |
DECIPHER | PDE6B [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | PDE6B |
| Mutations |
ICGC Data Portal | PDE6B |
TCGA Data Portal | PDE6B |
Broad Tumor Portal | PDE6B |
OASIS Portal | PDE6B [ Somatic mutations - Copy number] |
Somatic Mutations in Cancer : COSMIC | PDE6B [overview] [genome browser] [tissue] [distribution] |
Somatic Mutations in Cancer : COSMIC3D | PDE6B |
Mutations and Diseases : HGMD | PDE6B |
LOVD (Leiden Open Variation Database) | Whole genome datasets |
LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
LOVD (Leiden Open Variation Database) | Eye diseases - LOVD |
BioMuta | search PDE6B |
DgiDB (Drug Gene Interaction Database) | PDE6B |
DoCM (Curated mutations) | PDE6B (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | PDE6B (select a term) |
intoGen | PDE6B |
Cancer3D | PDE6B(select the gene name) |
Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
---|
OMIM | 163500 180072 613801 |
Orphanet | 659 923 |
DisGeNET | PDE6B |
Medgen | PDE6B |
Genetic Testing Registry | PDE6B
|
NextProt | P35913 [Medical] |
TSGene | 5158 |
GENETests | PDE6B |
Target Validation | PDE6B |
Huge Navigator |
PDE6B [HugePedia] |
snp3D : Map Gene to Disease | 5158 |
BioCentury BCIQ | PDE6B |
ClinGen | PDE6B |
| Clinical trials, drugs, therapy |
---|
Chemical/Protein Interactions : CTD | 5158 |
Chemical/Pharm GKB Gene | PA33134 |
Clinical trial | PDE6B |
| Miscellaneous |
---|
canSAR (ICR) | PDE6B (select the gene name) |
DataMed Index | PDE6B |
| Probes |
---|
| Litterature |
---|
PubMed | 48 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
CoreMine | PDE6B |
EVEX | PDE6B |
GoPubMed | PDE6B |
iHOP | PDE6B |