PDE8A (phosphodiesterase 8A)

2014-11-01  

Identity

HGNC
LOCATION
15q25.3
LOCUSID
ALIAS
HsT19550
FUSION GENES

Other Information

Locus ID:

NCBI: 5151
MIM: 602972
HGNC: 8793
Ensembl: ENSG00000073417

Variants:

dbSNP: 5151
ClinVar: 5151
TCGA: ENSG00000073417
COSMIC: PDE8A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000073417ENST00000310298O60658
ENSG00000073417ENST00000339708O60658
ENSG00000073417ENST00000394553O60658
ENSG00000073417ENST00000478717O60658
ENSG00000073417ENST00000485596E9PIJ0
ENSG00000073417ENST00000557957O60658
ENSG00000073417ENST00000559086H0YNP3
ENSG00000073417ENST00000559742H0YKR1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Purine metabolismKEGGhsa00230
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
275606982016Genomewide Association Study of African Children Identifies Association of SCHIP1 and PDE8A with Facial Size and Shape.23
189831672008Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity.22
126814442003Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans.21
235092992013Phosphodiesterase-8A binds to and regulates Raf-1 kinase.16
252291502014Active site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling.16
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
155967292004Per-Arnt-Sim domain-dependent association of cAMP-phosphodiesterase 8A1 with IkappaB proteins.8
226735732012Cyclic AMP-specific phosphodiesterase, PDE8A1, is activated by protein kinase A-mediated phosphorylation.8
194829042009PDE8A genetic variation, polycystic ovary syndrome and androgen levels in women.7

Citation

Dessen P

PDE8A (phosphodiesterase 8A)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71800/pde8a