PDF (peptide deformylase, mitochondrial)

2007-02-01  

Identity

HGNC
PDF
LOCATION
16q22.1
LOCUSID
64146
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64146
MIM: 618720
HGNC: 30012
Ensembl: ENSG00000258429

Variants:

dbSNP: 64146
ClinVar: 64146
TCGA: ENSG00000258429
COSMIC: PDF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000258429ENST00000288022Q9HBH1
ENSG00000258429ENST00000288022A0A024R6Y3

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
190645712008Polymorphisms in mitochondrial genes and prostate cancer risk.20
146371382003A new human peptide deformylase inhibitable by actinonin.19
192368782009Structure and activity of human mitochondrial peptide deformylase, a novel cancer target.12
246754702014Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressing hematopoietic cancers.10
238158822013Overexpression of peptide deformylase in breast, colon, and lung cancers.5
225545132012Transcriptional regulation of the human mitochondrial peptide deformylase (PDF).4
218051482012Successful COG8 and PDF overlap is mediated by alterations in splicing and polyadenylation signals.2
270234952016Structure-Based Drug Design of Small Molecule Peptide Deformylase Inhibitors to Treat Cancer.0

Citation

Dessen P

PDF (peptide deformylase, mitochondrial)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46225/pdf