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PDGFRA (platelet-derived growth factor receptor, alpha polypeptide)

Identity

Other namesCD140A
MGC74795
PDGFR2
RHEPDGFRA
HGNC (Hugo) PDGFRA
Location 4q12
Location_base_pair Starts at 54790021 and ends at 54859169 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Breakpoints

 

External links

Nomenclature
HGNC (Hugo)PDGFRA   8803
Entrez_Gene (NCBI)PDGFRA  5156  platelet-derived growth factor receptor, alpha polypeptide
Cards
GeneCards (Weizmann)PDGFRA
Ensembl (Hinxton)ENSG00000134853 [Gene_View]  PDGFRA [Vega]
AceView (NCBI)PDGFRA
Genatlas (Paris)PDGFRA
euGene (Indiana)5156
SOURCE (Stanford)NM_006206
Gene Expression (Array Express) ENSG00000134853
Genomic and cartography
GoldenPath (UCSC)PDGFRA  -  4q12   chr4:54790021-54859169 +  4q12   [Description]    (hg18-March_2006)
EnsemblPDGFRA - 4q12 [CytoView]
Mapping of homologs : NCBIPDGFRA [Mapview]
OMIM173490   606764   607685   
Gene and transcription
Gene : Genbank (Entrez)AA599881 AA625689 AK308353 AK311006 AK316578
Reference sequence (RefSeq transcript) :SRSNM_006206
Reference transcript : EntrezNM_006206
RefSeq genomic : SRSAC_000047 AC_000136 NC_000004 NG_009250 NT_022853 NW_001838913 NW_922162
RefSeq genomic : EntrezAC_000047 AC_000136 NC_000004 NG_009250 NT_022853 NW_001838913 NW_922162
Consensus coding sequences : CCDS NCBIPDGFRA
Cluster EST : UnigeneHs.74615 [ SRS ] Hs.74615 [ NCBI ]
Alternative Splicing : Fast-db (Paris)4387
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtP16234 (SRS) P16234 (Expasy) P16234 (Uniprot)
With graphics : InterProP16234
Splice isoforms : VarSplice FASTAP16234(VarSplice FASTA)
Domaine pattern : Prosite (SRS)IG_LIKE (PS50835)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_III (PS00240)   
Domain pattern : Prosite (Expaxy)IG_LIKE (PS50835)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    RECEPTOR_TYR_KIN_III (PS00240)   
Domains : Interpro (SRS)Ig-like    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Tyr_prot_kinase    Tyr_prot_kinase_AS    Tyr_prot_kinase_cat_dom    Tyr_prot_kinase_CSF1/PDGF_rcpt    Tyr_prot_kinase_PDGF_rcpt_a    Tyr_prot_kinase_rcpt_3_CS    Tyr_prot_kinase_subgr_cat_dom    Tyr_prot_kinase_VEGFR_rcpt_N   
Domains : Interpro (EBI)Ig-like    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Tyr_prot_kinase    Tyr_prot_kinase_AS    Tyr_prot_kinase_cat_dom    Tyr_prot_kinase_CSF1/PDGF_rcpt    Tyr_prot_kinase_PDGF_rcpt_a    Tyr_prot_kinase_rcpt_3_CS    Tyr_prot_kinase_subgr_cat_dom    Tyr_prot_kinase_VEGFR_rcpt_N   
Related proteins : CluSTrP16234
Domain families : Pfam SRSI-set (PF07679)    Pkinase_Tyr (PF07714)   
Domain families : Pfam SangerI-set (PF07679)    Pkinase_Tyr (PF07714)   
Domain families : Pfam NCBIpfam07679    pfam07714   
Domain families : Smart EMBLIG (SM00409)  IGc2 (SM00408)  TyrKc (SM00219)  
Blocks (Seattle)P16234
Crystal structure of protein : PDB SRS1GQ5   
Crystal structure of protein : PDBSum1GQ5   
Crystal structure of protein : IMB1GQ5   
Crystal structure of protein : PDB RSDB1GQ5   
HPRD01429
Protein Interaction databases
DIP (DOE-UCLA)P16234
IntAct (EBI)P16234
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIPDGFRA
SNP : GeneSNP UtahPDGFRA
SNP : HGBasePDGFRA
Genetic variants : HAPMAPPDGFRA
Cancer Gene: CensusPDGFRA 
Somatic Mutations in Cancer : COSMICPDGFRA 
Translocation Breakpoints in Cancer : TICdbnucleotide 
Mutations and Diseases : HGMDPDGFRA
Hereditary diseases : OMIM173490    606764    607685   
Hereditary diseases : GENETests173490    606764    607685   
Diseases : Genetic AssociationPDGFRA
General knowledge
Homologs : HomoloGenePDGFRA
Homology/Alignments : Family Browser UCSCPDGFRA
Phylogenetic Trees/Animal Genes : TreeFamPDGFRA
Catalytic activity : Enzyme2.7.10.1 [ Enzyme-Expasy ]   2.7.10.1 [ Enzyme-SRS ]   2.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   
Chemical/Protein Interactions : CTD5156
Keywords Ontology : AmiGOnucleotide binding  in utero embryonic development  cell activation  receptor activity  platelet-derived growth factor alpha-receptor activity  vascular endothelial growth factor receptor activity  platelet-derived growth factor receptor binding  ATP binding  plasma membrane  integral to plasma membrane  response to hormone stimulus  response to inorganic substance  transferase activity  peptidyl-tyrosine phosphorylation  extracellular matrix organization  lung development  positive regulation of cell migration  male genitalia development  response to estradiol stimulus  response to cytokine stimulus  wound healing  gliogenesis  odontogenesis of dentine-containing tooth  protein homodimerization activity  positive regulation of DNA replication  protein amino acid autophosphorylation  protein heterodimerization activity  platelet-derived growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  positive regulation of fibroblast proliferation  platelet-derived growth factor binding  skeletal system morphogenesis  inner ear development  response to hyperoxia  palate development  face morphogenesis  
Keywords Ontology : EGO-EBInucleotide binding  in utero embryonic development  cell activation  receptor activity  platelet-derived growth factor alpha-receptor activity  vascular endothelial growth factor receptor activity  platelet-derived growth factor receptor binding  ATP binding  plasma membrane  integral to plasma membrane  response to hormone stimulus  response to inorganic substance  transferase activity  peptidyl-tyrosine phosphorylation  extracellular matrix organization  lung development  positive regulation of cell migration  male genitalia development  response to estradiol stimulus  response to cytokine stimulus  wound healing  gliogenesis  odontogenesis of dentine-containing tooth  protein homodimerization activity  positive regulation of DNA replication  protein amino acid autophosphorylation  protein heterodimerization activity  platelet-derived growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  positive regulation of fibroblast proliferation  platelet-derived growth factor binding  skeletal system morphogenesis  inner ear development  response to hyperoxia  palate development  face morphogenesis  
Pathways : BIOCARTACBL mediated ligand-induced downregulation of EGF receptors [Genes]    Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration [Genes]    Phospholipids as signalling intermediaries [Genes]    Erk1/Erk2 Mapk Signaling pathway [Genes]    PDGF Signaling Pathway [Genes]    Rac 1 cell motility signaling pathway [Genes]   
Pathways : KEGGMAPK signaling pathwayCalcium signaling pathwayCytokine-cytokine receptor interactionFocal adhesionGap junctionRegulation of actin cytoskeletonColorectal cancer
Other databases
Probes
Probes : ImagenesPDGFRA Related clones (RZPD - Berlin)
Literature
PubMed192 Pubmed reference(s) in Entrez
PubGenePDGFRA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

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indexed on : Sat Feb 27 10:37:25 CET 2010
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