PDHX (pyruvate dehydrogenase complex component X)

2007-02-01  

Identity

HGNC
LOCATION
11p13
LOCUSID
ALIAS
DLDBP,E3BP,OPDX,PDHXD,PDX1,proX
FUSION GENES

Other Information

Locus ID:

NCBI: 8050
MIM: 608769
HGNC: 21350
Ensembl: ENSG00000110435

Variants:

dbSNP: 8050
ClinVar: 8050
TCGA: ENSG00000110435
COSMIC: PDHX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110435ENST00000227868O00330
ENSG00000110435ENST00000430469O00330
ENSG00000110435ENST00000448838O00330
ENSG00000110435ENST00000526309H0YD97
ENSG00000110435ENST00000533262E9PRI6
ENSG00000110435ENST00000533550E9PLU0

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Metabolic pathwaysKEGGhsa01100
Signal TransductionREACTOMER-HSA-162582
Signaling by Retinoic AcidREACTOMER-HSA-5362517
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycleREACTOMER-HSA-71406
Pyruvate metabolismREACTOMER-HSA-70268
Regulation of pyruvate dehydrogenase (PDH) complexREACTOMER-HSA-204174
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Glyoxylate metabolism and glycine degradationREACTOMER-HSA-389661

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
249352202014MicroRNA-26a regulates glucose metabolism by direct targeting PDHX in colorectal cancer cells.44
211946772011Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study.43
146386922004Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components.35
164428032006Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex.26
162637182006How dihydrolipoamide dehydrogenase-binding protein binds dihydrolipoamide dehydrogenase in the human pyruvate dehydrogenase complex.22
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
300121702018Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer.10
165660172006Leigh's disease due to a new mutation in the PDHX gene.5
170244562007Enzyme-assisted photosensitization with rose Bengal acetate induces structural and functional alteration of mitochondria in HeLa cells.4

Citation

Dessen P

PDHX (pyruvate dehydrogenase complex component X)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43932/pdhx