PDIA4 (protein disulfide isomerase family A member 4)

2012-01-01  

Identity

HGNC
PDIA4
LOCATION
7q36.1
LOCUSID
9601
ALIAS
ERP70,ERP72,ERp-72
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9601
HGNC: 30167
Ensembl: ENSG00000155660

Variants:

dbSNP: 9601
ClinVar: 9601
TCGA: ENSG00000155660
COSMIC: PDIA4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155660ENST00000286091A0A499FI48
ENSG00000155660ENST00000413966C9JMN9
ENSG00000155660ENST00000652332P13667
ENSG00000155660ENST00000652332A0A090N8Y2

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vibrio cholerae infectionKEGGko05110
Vibrio cholerae infectionKEGGhsa05110
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
198345352009Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.27
217432962011Quantitative tissue proteomics of esophageal squamous cell carcinoma for novel biomarker discovery.27
244642232014The protein disulfide isomerases PDIA4 and PDIA6 mediate resistance to cisplatin-induced cell death in lung adenocarcinoma.23
186205482008A possible biochemical link between NADPH oxidase (Nox) 1 redox-signalling and ERp72.6
285345132017Protein disulfide isomerase a4 acts as a novel regulator of cancer growth through the procaspase pathway.4
245999572014Transient covalent interactions of newly synthesized thyroglobulin with oxidoreductases of the endoplasmic reticulum.3
284870272017Interleukin-11 up-regulates endoplasmic reticulum stress induced target, PDIA4 in human first trimester placenta and in vivo in mice.2
286509932017A novel potential biomarker for metabolic syndrome in Chinese adults: Circulating protein disulfide isomerase family A, member 4.1

Citation

Dessen P

PDIA4 (protein disulfide isomerase family A member 4)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52569/pdia4