PDIA6 (protein disulfide isomerase family A member 6)

2012-10-01  

Identity

HGNC
PDIA6
LOCATION
2p25.1
LOCUSID
10130
ALIAS
ERP5,P5,TXNDC7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10130
MIM: 611099
HGNC: 30168
Ensembl: ENSG00000143870

Variants:

dbSNP: 10130
ClinVar: 10130
TCGA: ENSG00000143870
COSMIC: PDIA6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143870ENST00000272227Q15084
ENSG00000143870ENST00000272227A0A384NPU5
ENSG00000143870ENST00000381611Q15084
ENSG00000143870ENST00000404371Q15084
ENSG00000143870ENST00000404824Q15084
ENSG00000143870ENST00000458536C9JNG5
ENSG00000143870ENST00000540494Q15084
ENSG00000143870ENST00000617249Q15084

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
174959322007Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands.109
198875852009Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
154669362005A role for the thiol isomerase protein ERP5 in platelet function.51
221677532012High ERp5/ADAM10 expression in lymph node microenvironment and impaired NKG2D ligands recognition in Hodgkin lymphomas.32
244642232014The protein disulfide isomerases PDIA4 and PDIA6 mediate resistance to cisplatin-induced cell death in lung adenocarcinoma.23
122041152002Functional analysis of human P5, a protein disulfide isomerase homologue.18
222151382012Expression of ERp5 and GRP78 on the membrane of chronic lymphocytic leukemia cells: association with soluble MICA shedding.16
248430472014Thioredoxin-interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress.15
274628662016PDIA6 promotes the proliferation of HeLa cells through activating the Wnt/β-catenin signaling pathway.12

Citation

Dessen P

PDIA6 (protein disulfide isomerase family A member 6)

Atlas Genet Cytogenet Oncol Haematol. 2012-10-01

Online version: http://atlasgeneticsoncology.org/gene/52908/pdia6