Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5163
MIM: 602524
HGNC: 8809
Ensembl: ENSG00000152256
Variants:
dbSNP: 5163
ClinVar: 5163
TCGA: ENSG00000152256
COSMIC: PDK1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA24684 | AKT1 | Gene | Pathway | associated | 22336956 | ||
| PA448871 | celecoxib | Chemical | Pathway | associated | 22336956 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37905340 | 2024 | RP11-495P10.1 promotes HCC cell proliferation by regulating reprogramming of glucose metabolism and acetylation of the NR4A3 promoter via the PDK1/PDH axis. | 0 |
| 38199564 | 2024 | Circadian modulation of glucose utilization via CRY1-mediated repression of Pdk1 expression. | 0 |
| 38353358 | 2024 | Glutaminase potentiates the glycolysis in esophageal squamous cell carcinoma by interacting with PDK1. | 0 |
| 38733179 | 2024 | Long non-coding RNA NEAT1 promotes aerobic glycolysis and progression of cervical cancer through WNT/β-catenin/PDK1 axis. | 1 |
| 37905340 | 2024 | RP11-495P10.1 promotes HCC cell proliferation by regulating reprogramming of glucose metabolism and acetylation of the NR4A3 promoter via the PDK1/PDH axis. | 0 |
| 38199564 | 2024 | Circadian modulation of glucose utilization via CRY1-mediated repression of Pdk1 expression. | 0 |
| 38353358 | 2024 | Glutaminase potentiates the glycolysis in esophageal squamous cell carcinoma by interacting with PDK1. | 0 |
| 38733179 | 2024 | Long non-coding RNA NEAT1 promotes aerobic glycolysis and progression of cervical cancer through WNT/β-catenin/PDK1 axis. | 1 |
| 36331285 | 2023 | Circ_0000284 facilitates the growth, metastasis and glycolysis of intrahepatic cholangiocarcinoma through miR-152-3p-mediated PDK1 expression. | 0 |
| 36334805 | 2023 | CircRAD54L2 promotes triple-negative breast cancer progression by regulating the miR-888 family/PDK1 axis. | 3 |
| 36866436 | 2023 | Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk. | 11 |
| 36988347 | 2023 | PDK1 regulates the progression of esophageal squamous cell carcinoma through metabolic reprogramming. | 1 |
| 37014317 | 2023 | Circular RNA PDK1 targets miR-4731-5p to enhance TNXB expression in ligamentum flavum hypertrophy. | 2 |
| 37042573 | 2023 | PDK1-stabilized LncRNA SPRY4-IT1 promotes breast cancer progression via activating NF-κB signaling pathway. | 0 |
| 37141697 | 2023 | Long non-coding RNA TCL6 induced by SCRT1 promotes proliferation and metastasis of non-small cell lung cancer through PDK1/AKT signaling. | 1 |
Citation
Dessen P
PDK1 (pyruvate dehydrogenase kinase 1)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43405/pdk1
