PDK2 (pyruvate dehydrogenase kinase 2)

2003-05-01  

Identity

HGNC
PDK2
LOCATION
17q21.33
LOCUSID
5164
ALIAS
PDHK2,PDKII
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5164
MIM: 602525
HGNC: 8810
Ensembl: ENSG00000005882

Variants:

dbSNP: 5164
ClinVar: 5164
TCGA: ENSG00000005882
COSMIC: PDK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000005882ENST00000007708Q15119
ENSG00000005882ENST00000503176Q15119
ENSG00000005882ENST00000503614D6RDN9
ENSG00000005882ENST00000505440D6RJH7
ENSG00000005882ENST00000508030D6RHG2
ENSG00000005882ENST00000510219D6R983
ENSG00000005882ENST00000512238D6RGV8
ENSG00000005882ENST00000614357Q15119

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Retinoic AcidREACTOMER-HSA-5362517
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycleREACTOMER-HSA-71406
Pyruvate metabolismREACTOMER-HSA-70268
Regulation of pyruvate dehydrogenase (PDH) complexREACTOMER-HSA-204174

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
221239262012p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2.70
226140042013Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer.62
233767762013Nutrient deprivation induces the Warburg effect through ROS/AMPK-dependent activation of pyruvate dehydrogenase kinase.42
191477522009Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in head and neck squamous cell carcinoma.39
164010712006Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands.37
176694202007Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta.37
233002592013Epidemiology of autosomal-dominant polycystic kidney disease: an in-depth clinical study for south-western Germany.33
159550602005Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells.27
243569702014Structure-guided development of specific pyruvate dehydrogenase kinase inhibitors targeting the ATP-binding pocket.25
266079042016Activation of mitochondrial oxidation by PDK2 inhibition reverses cisplatin resistance in head and neck cancer.21

Citation

Dessen P

PDK2 (pyruvate dehydrogenase kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41683/pdk2