PDLIM2 (PDZ and LIM domain 2)

2010-05-01  

Identity

HGNC
PDLIM2
LOCATION
8p21.3
LOCUSID
64236
ALIAS
MYSTIQUE,SLIM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64236
MIM: 609722
HGNC: 13992
Ensembl: ENSG00000120913

Variants:

dbSNP: 64236
ClinVar: 64236
TCGA: ENSG00000120913
COSMIC: PDLIM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120913ENST00000265810Q96JY6
ENSG00000120913ENST00000308354Q96JY6
ENSG00000120913ENST00000339162Q96JY6
ENSG00000120913ENST00000397760Q96JY6
ENSG00000120913ENST00000397761Q96JY6
ENSG00000120913ENST00000409141Q96JY6
ENSG00000120913ENST00000409417Q96JY6
ENSG00000120913ENST00000416159F8WFB8
ENSG00000120913ENST00000426493C9J0X3
ENSG00000120913ENST00000429812C9K0F0
ENSG00000120913ENST00000436754C9J760
ENSG00000120913ENST00000443561A0A087WUQ1
ENSG00000120913ENST00000448520A0A087WXJ0
ENSG00000120913ENST00000452226C9JS55
ENSG00000120913ENST00000456545C9JSR2
ENSG00000120913ENST00000464275B3KPU0
ENSG00000120913ENST00000614502B3KPU0
ENSG00000120913ENST00000616289A0A087WU48
ENSG00000120913ENST00000622702A0A087WVI1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
174687592007PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit.108
156596422005Mystique is a new insulin-like growth factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses Anchorage-independent growth.39
201858232010Epigenetic repression of PDZ-LIM domain-containing protein 2: implications for the biology and treatment of breast cancer.28
208383822010Molecular determinants of PDLIM2 in suppressing HTLV-I Tax-mediated tumorigenesis.26
256814432015Oncovirus Kaposi sarcoma herpesvirus (KSHV) represses tumor suppressor PDLIM2 to persistently activate nuclear factor κB (NF-κB) and STAT3 transcription factors for tumorigenesis and tumor maintenance.17
268635702016Long noncoding RNA OR3A4 promotes metastasis and tumorigenicity in gastric cancer.16
197949622009Human T-cell leukemia virus type I-mediated repression of PDZ-LIM domain-containing protein 2 involves DNA methylation but independent of the viral oncoprotein tax.15
235844822014PDLIM2 expression is driven by vitamin D and is involved in the pro-adhesion, and anti-migration and -invasion activity of vitamin D.15
190521462009Sequestration of PDLIM2 in the cytoplasm of monocytic/macrophage cells is associated with adhesion and increased nuclear activity of NF-kappaB.13
241968352014PDLIM2 regulates transcription factor activity in epithelial-to-mesenchymal transition via the COP9 signalosome.12

Citation

Dessen P

PDLIM2 (PDZ and LIM domain 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51491/pdlim2