Identity
HGNC
LOCATION
8q22.1
LOCUSID
ALIAS
PDH,PDP,PDPC,PPM2A,PPM2C
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 54704
MIM: 605993
HGNC: 9279
Ensembl: ENSG00000164951
Variants:
dbSNP: 54704
ClinVar: 54704
TCGA: ENSG00000164951
COSMIC: PDP1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38566355 | 2024 | PDP1 promotes the progression of breast cancer through STAT3 pathway. | 0 |
| 38566355 | 2024 | PDP1 promotes the progression of breast cancer through STAT3 pathway. | 0 |
| 37935978 | 2023 | PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia. | 0 |
| 37935978 | 2023 | PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia. | 0 |
| 34489398 | 2021 | Mitochondrial dysfunction induces radioresistance in colorectal cancer by activating [Ca(2+)](m)-PDP1-PDH-histone acetylation retrograde signaling. | 13 |
| 34489398 | 2021 | Mitochondrial dysfunction induces radioresistance in colorectal cancer by activating [Ca(2+)](m)-PDP1-PDH-histone acetylation retrograde signaling. | 13 |
| 28148899 | 2017 | Regulation of hepatic pyruvate dehydrogenase phosphorylation in offspring glucose intolerance induced by intrauterine hyperglycemia. | 2 |
| 28148899 | 2017 | Regulation of hepatic pyruvate dehydrogenase phosphorylation in offspring glucose intolerance induced by intrauterine hyperglycemia. | 2 |
| 24486017 | 2014 | Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex. | 134 |
| 24962578 | 2014 | Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth. | 24 |
| 24486017 | 2014 | Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex. | 134 |
| 24962578 | 2014 | Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth. | 24 |
| 21680880 | 2011 | Exercise-induced pyruvate dehydrogenase activation is not affected by 7 days of bed rest. | 9 |
| 21680880 | 2011 | Exercise-induced pyruvate dehydrogenase activation is not affected by 7 days of bed rest. | 9 |
| 20208177 | 2010 | Crystallization and preliminary crystallographic studies of the catalytic subunits of human pyruvate dehydrogenase phosphatase isoforms 1 and 2. | 1 |
Citation
Dessen P
PDP1 (pyruvate dehydrogenase phosphatase catalytic subunit 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/47314/pdp1
