PDPN (podoplanin)

2003-05-01  

Identity

HGNC
LOCATION
1p36.21
LOCUSID
ALIAS
AGGRUS,GP36,GP40,Gp38,HT1A-1,OTS8,PA2.26,T1A,T1A-2,T1A2,TI1A
FUSION GENES

Other Information

Locus ID:

NCBI: 10630
MIM: 608863
HGNC: 29602
Ensembl: ENSG00000162493

Variants:

dbSNP: 10630
ClinVar: 10630
TCGA: ENSG00000162493
COSMIC: PDPN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162493ENST00000294489Q86YL7
ENSG00000162493ENST00000376057Q86YL7
ENSG00000162493ENST00000376061Q86YL7
ENSG00000162493ENST00000475043Q86YL7
ENSG00000162493ENST00000487038Q86YL7
ENSG00000162493ENST00000488631D6RH07
ENSG00000162493ENST00000506205H0Y8Q3
ENSG00000162493ENST00000509009E7ETC6
ENSG00000162493ENST00000510906H0YA72
ENSG00000162493ENST00000513143Q86YL7
ENSG00000162493ENST00000617617Q86YL7
ENSG00000162493ENST00000621990Q86YL7

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
GPVI-mediated activation cascadeREACTOMER-HSA-114604

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
166163322006Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton.175
176165322007Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells.143
157438022005Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors.137
171799892007The potential role of podoplanin in tumour invasion.89
155150192005Characterization of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas.83
145229832003Molecular identification of Aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors.80
165964242006Increased expression of podoplanin in malignant astrocytic tumors as a novel molecular marker of malignant progression.72
185462642008Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma.64
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
239912012013Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2.55

Citation

Dessen P

PDPN (podoplanin)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42455/pdpn