PDXP (pyridoxal phosphatase)

2016-10-01  

Identity

HGNC
PDXP
LOCATION
22q13.1
LOCUSID
57026
ALIAS
CIN,PLP,dJ37E16.5

Other Information

Locus ID:

NCBI: 57026
MIM: 609246
HGNC: 30259
Ensembl: ENSG00000241360

Variants:

dbSNP: 57026
ClinVar: 57026
TCGA: ENSG00000241360
COSMIC: PDXP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000241360ENST00000215904Q96GD0
ENSG00000241360ENST00000215904A0A024R1I3
ENSG00000241360ENST00000403251B1AHD3

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vitamin B6 metabolismKEGGko00750
Vitamin B6 metabolismKEGGhsa00750
Metabolic pathwaysKEGGhsa01100

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
155802682005Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics.117
190008342008Chronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation.48
145229542003Human pyridoxal phosphatase. Molecular cloning, functional expression, and tissue distribution.21
232235682013A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation.9
263248842015Chronophin coordinates cell leading edge dynamics by controlling active cofilin levels.4
185108742008Human brain pyridoxal-5'-phosphate phosphatase (PLPP):protein transduction of PEP-1-PLPP into PC12 cells.3
297241932018Chronophin regulates active vitamin B6 levels and transcriptomic features of glioblastoma cell lines cultured under non-adherent, serum-free conditions.1
163367862005Human brain pyridoxal-5'-phosphate phosphatase: production and characterization of monoclonal antibodies.0

Citation

Dessen P

PDXP (pyridoxal phosphatase)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56303/pdxp