PEAR1 (platelet endothelial aggregation receptor 1)

2014-11-01  

Identity

HGNC
LOCATION
1q23.1
LOCUSID
ALIAS
JEDI,MEGF12

Other Information

Locus ID:

NCBI: 375033
MIM: 610278
HGNC: 33631
Ensembl: ENSG00000187800

Variants:

dbSNP: 375033
ClinVar: 375033
TCGA: ENSG00000187800
COSMIC: PEAR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187800ENST00000292357Q5VY43
ENSG00000187800ENST00000338302Q5VY43
ENSG00000187800ENST00000444016F2Z2F7
ENSG00000187800ENST00000455314A6PVP2

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA154410481prasugrelChemicalClinicalAnnotationassociatedPD23859572, 28820077
PA165374673ticagrelorChemicalClinicalAnnotationassociatedPD27937053
PA445019Myocardial InfarctionDiseaseClinicalAnnotationassociatedPD23392654
PA448497aspirinChemicalClinicalAnnotationassociatedPD23392654, 23859572, 28820077
PA449053clopidogrelChemicalClinicalAnnotationassociatedPD23392654, 26962983, 28820077

References

Pubmed IDYearTitleCitations
205263382010Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.84
194298682009A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways.46
257131222015A Human Platelet Receptor Protein Microarray Identifies the High Affinity Immunoglobulin E Receptor Subunit α (FcεR1α) as an Activating Platelet Endothelium Aggregation Receptor 1 (PEAR1) Ligand.14
257035202015Different models of inheritance in selected genes in patients with sticky platelet syndrome and fetal loss.6
276417362016Associations of MDR1, TBXA2R, PLA2G7, and PEAR1 genetic polymorphisms with the platelet activity in Chinese ischemic stroke patients receiving aspirin therapy.5
296352522018Study of the Association of PEAR1, P2Y12, and UGT2A1 Polymorphisms with Platelet Reactivity in Response to Dual Antiplatelet Therapy in Chinese Patients.3
307004162019Synthetic glycopolymers and natural fucoidans cause human platelet aggregation via PEAR1 and GPIbα.3
158514712005Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation.0
185116962008A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregability.0
185116962008A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregability.0

Citation

Dessen P

PEAR1 (platelet endothelial aggregation receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71822/pear1