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PELI2 (pellino E3 ubiquitin protein ligase family member 2)

Identity

Alias (NCBI)-
HGNC (Hugo) PELI2
HGNC Previous namepellino (Drosophila) homolog 2
 pellino homolog 2 (Drosophila)
LocusID (NCBI) 57161
Atlas_Id 46093
Location 14q22.3  [Link to chromosome band 14q22]
Location_base_pair Starts at 56118411 and ends at 56301524 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PELI2 (14q22.3) / USP28 (11q23.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(14;14)(q22;q23) PELI2/C14orf39

External links

Nomenclature
HGNC (Hugo)PELI2   8828
Cards
Entrez_Gene (NCBI)PELI2    pellino E3 ubiquitin protein ligase family member 2
Aliases
GeneCards (Weizmann)PELI2
Ensembl hg19 (Hinxton)ENSG00000139946 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000139946 [Gene_View]  ENSG00000139946 [Sequence]  chr14:56118411-56301524 [Contig_View]  PELI2 [Vega]
ICGC DataPortalENSG00000139946
TCGA cBioPortalPELI2
AceView (NCBI)PELI2
Genatlas (Paris)PELI2
SOURCE (Princeton)PELI2
Genetics Home Reference (NIH)PELI2
Genomic and cartography
GoldenPath hg38 (UCSC)PELI2  -     chr14:56118411-56301524 +  14q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PELI2  -     14q22.3   [Description]    (hg19-Feb_2009)
GoldenPathPELI2 - 14q22.3 [CytoView hg19]  PELI2 - 14q22.3 [CytoView hg38]
ImmunoBaseENSG00000139946
genome Data Viewer NCBIPELI2 [Mapview hg19]  
OMIM614798   
Gene and transcription
Genbank (Entrez)AF302502 AK025208 AK315727 AL133605 AL709755
RefSeq transcript (Entrez)NM_021255
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PELI2
Alternative Splicing GalleryENSG00000139946
Gene ExpressionPELI2 [ NCBI-GEO ]   PELI2 [ EBI - ARRAY_EXPRESS ]   PELI2 [ SEEK ]   PELI2 [ MEM ]
Gene Expression Viewer (FireBrowse)PELI2 [ Firebrowse - Broad ]
GenevisibleExpression of PELI2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57161
GTEX Portal (Tissue expression)PELI2
Human Protein AtlasENSG00000139946-PELI2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HAT8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HAT8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HAT8
Splice isoforms : SwissVarQ9HAT8
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9HAT8
Domains : Interpro (EBI)Pellino_fam   
Domain families : Pfam (Sanger)Pellino (PF04710)   
Domain families : Pfam (NCBI)pfam04710   
Conserved Domain (NCBI)PELI2
Blocks (Seattle)PELI2
PDB (RSDB)3EGA    3EGB   
PDB Europe3EGA    3EGB   
PDB (PDBSum)3EGA    3EGB   
PDB (IMB)3EGA    3EGB   
Structural Biology KnowledgeBase3EGA    3EGB   
SCOP (Structural Classification of Proteins)3EGA    3EGB   
CATH (Classification of proteins structures)3EGA    3EGB   
SuperfamilyQ9HAT8
Human Protein Atlas [tissue]ENSG00000139946-PELI2 [tissue]
Peptide AtlasQ9HAT8
HPRD17835
IPIIPI00009753   IPI00386231   
Protein Interaction databases
DIP (DOE-UCLA)Q9HAT8
IntAct (EBI)Q9HAT8
BioGRIDPELI2
STRING (EMBL)PELI2
ZODIACPELI2
Ontologies - Pathways
QuickGOQ9HAT8
Ontology : AmiGOprotein polyubiquitination  positive regulation of protein phosphorylation  protein binding  cytosol  Toll signaling pathway  regulation of Toll signaling pathway  ubiquitin-ubiquitin ligase activity  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of MAPK cascade  ubiquitin protein ligase activity  interleukin-1-mediated signaling pathway  
Ontology : EGO-EBIprotein polyubiquitination  positive regulation of protein phosphorylation  protein binding  cytosol  Toll signaling pathway  regulation of Toll signaling pathway  ubiquitin-ubiquitin ligase activity  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of MAPK cascade  ubiquitin protein ligase activity  interleukin-1-mediated signaling pathway  
NDEx NetworkPELI2
Atlas of Cancer Signalling NetworkPELI2
Wikipedia pathwaysPELI2
Orthology - Evolution
OrthoDB57161
GeneTree (enSembl)ENSG00000139946
Phylogenetic Trees/Animal Genes : TreeFamPELI2
HOGENOMQ9HAT8
Homologs : HomoloGenePELI2
Homology/Alignments : Family Browser (UCSC)PELI2
Gene fusions - Rearrangements
Fusion : QuiverPELI2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPELI2 [hg38]
dbVarPELI2
ClinVarPELI2
MonarchPELI2
1000_GenomesPELI2 
Exome Variant ServerPELI2
GNOMAD BrowserENSG00000139946
Varsome BrowserPELI2
Genomic Variants (DGV)PELI2 [DGVbeta]
DECIPHERPELI2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPELI2 
Mutations
ICGC Data PortalPELI2 
TCGA Data PortalPELI2 
Broad Tumor PortalPELI2
OASIS PortalPELI2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPELI2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPELI2
Mutations and Diseases : HGMDPELI2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PELI2
DgiDB (Drug Gene Interaction Database)PELI2
DoCM (Curated mutations)PELI2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PELI2 (select a term)
intoGenPELI2
Cancer3DPELI2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614798   
Orphanet
DisGeNETPELI2
MedgenPELI2
Genetic Testing Registry PELI2
NextProtQ9HAT8 [Medical]
GENETestsPELI2
Target ValidationPELI2
Huge Navigator PELI2 [HugePedia]
ClinGenPELI2
Clinical trials, drugs, therapy
MyCancerGenomePELI2
Protein Interactions : CTD
Pharm GKB GenePA33173
PharosQ9HAT8
Clinical trialPELI2
Miscellaneous
canSAR (ICR)PELI2 (select the gene name)
HarmonizomePELI2
DataMed IndexPELI2
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPELI2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:31:01 CET 2021
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