PELI3 (pellino E3 ubiquitin protein ligase family member 3)

2014-04-01  

Identity

HGNC
PELI3
LOCATION
11q13.2
LOCUSID
246330
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 246330
MIM: 609827
HGNC: 30010
Ensembl: ENSG00000174516

Variants:

dbSNP: 246330
ClinVar: 246330
TCGA: ENSG00000174516
COSMIC: PELI3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174516ENST00000320740Q8N2H9
ENSG00000174516ENST00000320740A0A024R5B1
ENSG00000174516ENST00000349459Q8N2H9
ENSG00000174516ENST00000349459A0A024R5I2
ENSG00000174516ENST00000524466Q8N2H9
ENSG00000174516ENST00000526296E9PI91
ENSG00000174516ENST00000527230E9PQX6
ENSG00000174516ENST00000528752H0YEM6
ENSG00000174516ENST00000532970E9PR85
ENSG00000174516ENST00000618547Q8N2H9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 10 (TLR10) CascadeREACTOMER-HSA-168142
MyD88 cascade initiated on plasma membraneREACTOMER-HSA-975871
IRAK1 recruits IKK complexREACTOMER-HSA-937039
Toll Like Receptor 5 (TLR5) CascadeREACTOMER-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulationREACTOMER-HSA-975144
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-1 signalingREACTOMER-HSA-446652

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
238927232013Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis.32
183264982008Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation.23
159172472005Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner.14
263108312015Pellino-3 promotes endotoxin tolerance and acts as a negative regulator of TLR2 and TLR4 signaling.10
250276982014The pellino e3 ubiquitin ligases recognize specific phosphothreonine motifs and have distinct substrate specificities.4
280117112016Protective coding variants in CFH and PELI3 and a variant near CTRB1 are associated with age-related macular degeneration†.4
273026652017Differential modulation of Helicobacter pylori lipopolysaccharide-mediated TLR2 signaling by individual Pellino proteins.2

Citation

Dessen P

PELI3 (pellino E3 ubiquitin protein ligase family member 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-04-01

Online version: http://atlasgeneticsoncology.org/gene/53876/peli3