PER2 (period circadian regulator 2)

2007-02-01  

Identity

HGNC
PER2
LOCATION
2q37.3
LOCUSID
8864
ALIAS
FASPS,FASPS1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8864
MIM: 603426
HGNC: 8846
Ensembl: ENSG00000132326

Variants:

dbSNP: 8864
ClinVar: 8864
TCGA: ENSG00000132326
COSMIC: PER2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132326ENST00000254657O15055
ENSG00000132326ENST00000431832E9PD89

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Circadian rhythmKEGGko04710
Circadian rhythmKEGGhsa04710
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Circadian entrainmentKEGGhsa04713
Circadian entrainmentKEGGko04713
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
123722992002The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo.371
172182552007Modeling of a human circadian mutation yields insights into clock regulation by PER2.142
157905882005Deregulated expression of the PER1, PER2 and PER3 genes in breast cancers.119
225044832012Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia.110
200721162010Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.91
165287482006Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder.88
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
174577202007Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression.80
192995602009A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock.76
175990552007The clock gene Per2 links the circadian system to the estrogen receptor.66

Citation

Dessen P

PER2 (period circadian regulator 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46410/per2