PGAM5 (PGAM family member 5, mitochondrial serine/threonine protein phosphatase)

2019-04-01  

Identity

HGNC
LOCATION
12q24.33
LOCUSID
ALIAS
BXLBV68
FUSION GENES

Other Information

Locus ID:

NCBI: 192111
MIM: 614939
HGNC: 28763
Ensembl: ENSG00000247077

Variants:

dbSNP: 192111
ClinVar: 192111
TCGA: ENSG00000247077
COSMIC: PGAM5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000247077ENST00000317555Q96HS1
ENSG00000247077ENST00000454808F5GXG4
ENSG00000247077ENST00000498926Q96HS1
ENSG00000247077ENST00000543955F5GXG4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
222654142012The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways.309
247466962014A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy.110
170468352006PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex.77
195900152009Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1.45
229155952012Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.39
251267232014The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy.39
232011242013Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator.33
263812142015Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling.31
263568202015Bax-PGAM5L-Drp1 complex is required for intrinsic apoptosis execution.28
274530482016Identification of PGAM5 as a Mammalian Protein Histidine Phosphatase that Plays a Central Role to Negatively Regulate CD4(+) T Cells.19

Citation

Dessen P

PGAM5 (PGAM family member 5, mitochondrial serine/threonine protein phosphatase)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57925/pgam5