Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PGC (progastricsin)

Identity

Alias (NCBI)PEPC
PGII
HGNC (Hugo) PGC
HGNC Alias namepepsinogen C
HGNC Previous nameprogastricsin (pepsinogen C)
LocusID (NCBI) 5225
Atlas_Id 43776
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 41736711 and ends at 41747397 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GTF2H3 (12q24.31) / PGC (6p21.1)NCOR2 (12q24.31) / PGC (6p21.1)PGC (6p21.1) / PGC (6p21.1)
TFEB (6p21.1) / PGC (6p21.1)GTF2H3 12q24.31 / PGC 6p21.1NCOR2 12q24.31 / PGC 6p21.1
TFEB 6p21.1 / PGC 6p21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  TFEB/PGC (6p21)
t(6;12)(p21;q24) GTF2H3/PGC
t(6;12)(p21;q24) NCOR2/PGC

External links

Nomenclature
HGNC (Hugo)PGC   8890
Cards
Entrez_Gene (NCBI)PGC    progastricsin
AliasesPEPC; PGII
GeneCards (Weizmann)PGC
Ensembl hg19 (Hinxton)ENSG00000096088 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000096088 [Gene_View]  ENSG00000096088 [Sequence]  chr6:41736711-41747397 [Contig_View]  PGC [Vega]
ICGC DataPortalENSG00000096088
TCGA cBioPortalPGC
AceView (NCBI)PGC
Genatlas (Paris)PGC
SOURCE (Princeton)PGC
Genetics Home Reference (NIH)PGC
Genomic and cartography
GoldenPath hg38 (UCSC)PGC  -     chr6:41736711-41747397 -  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PGC  -     6p21.1   [Description]    (hg19-Feb_2009)
GoldenPathPGC - 6p21.1 [CytoView hg19]  PGC - 6p21.1 [CytoView hg38]
ImmunoBaseENSG00000096088
genome Data Viewer NCBIPGC [Mapview hg19]  
OMIM169740   
Gene and transcription
Genbank (Entrez)AK223274 AK301298 AK301325 BC042578 BC073740
RefSeq transcript (Entrez)NM_001166424 NM_002630
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PGC
Alternative Splicing GalleryENSG00000096088
Gene ExpressionPGC [ NCBI-GEO ]   PGC [ EBI - ARRAY_EXPRESS ]   PGC [ SEEK ]   PGC [ MEM ]
Gene Expression Viewer (FireBrowse)PGC [ Firebrowse - Broad ]
GenevisibleExpression of PGC in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5225
GTEX Portal (Tissue expression)PGC
Human Protein AtlasENSG00000096088-PGC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20142   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20142  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20142
Splice isoforms : SwissVarP20142
Catalytic activity : Enzyme3.4.23.3 [ Enzyme-Expasy ]   3.4.23.33.4.23.3 [ IntEnz-EBI ]   3.4.23.3 [ BRENDA ]   3.4.23.3 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP20142
Domaine pattern : Prosite (Expaxy)ASP_PROTEASE (PS00141)    PEPTIDASE_A1 (PS51767)   
Domains : Interpro (EBI)Aspartic_peptidase_A1    Aspartic_peptidase_AS    Aspartic_peptidase_N    PEPTIDASE_A1    Peptidase_aspartic_dom_sf   
Domain families : Pfam (Sanger)A1_Propeptide (PF07966)    Asp (PF00026)   
Domain families : Pfam (NCBI)pfam07966    pfam00026   
Conserved Domain (NCBI)PGC
Blocks (Seattle)PGC
PDB (RSDB)1AVF    1HTR   
PDB Europe1AVF    1HTR   
PDB (PDBSum)1AVF    1HTR   
PDB (IMB)1AVF    1HTR   
Structural Biology KnowledgeBase1AVF    1HTR   
SCOP (Structural Classification of Proteins)1AVF    1HTR   
CATH (Classification of proteins structures)1AVF    1HTR   
SuperfamilyP20142
Human Protein Atlas [tissue]ENSG00000096088-PGC [tissue]
Peptide AtlasP20142
HPRD01357
IPIIPI00022213   IPI00383359   IPI00910787   IPI00607684   IPI00792533   
Protein Interaction databases
DIP (DOE-UCLA)P20142
IntAct (EBI)P20142
BioGRIDPGC
STRING (EMBL)PGC
ZODIACPGC
Ontologies - Pathways
QuickGOP20142
Ontology : AmiGOpositive regulation of antibacterial peptide production  aspartic-type endopeptidase activity  extracellular space  extracellular space  digestion  
Ontology : EGO-EBIpositive regulation of antibacterial peptide production  aspartic-type endopeptidase activity  extracellular space  extracellular space  digestion  
NDEx NetworkPGC
Atlas of Cancer Signalling NetworkPGC
Wikipedia pathwaysPGC
Orthology - Evolution
OrthoDB5225
GeneTree (enSembl)ENSG00000096088
Phylogenetic Trees/Animal Genes : TreeFamPGC
HOGENOMP20142
Homologs : HomoloGenePGC
Homology/Alignments : Family Browser (UCSC)PGC
Gene fusions - Rearrangements
Fusion : MitelmanGTF2H3/PGC [12q24.31/6p21.1]  
Fusion : MitelmanNCOR2/PGC [12q24.31/6p21.1]  
Fusion : MitelmanTFEB/PGC [6p21.1/6p21.1]  
Fusion PortalGTF2H3 12q24.31 PGC 6p21.1 GBM
Fusion PortalNCOR2 12q24.31 PGC 6p21.1 LUAD
Fusion PortalTFEB 6p21.1 PGC 6p21.1 OV
Fusion : QuiverPGC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPGC [hg38]
dbVarPGC
ClinVarPGC
MonarchPGC
1000_GenomesPGC 
Exome Variant ServerPGC
GNOMAD BrowserENSG00000096088
Varsome BrowserPGC
Genomic Variants (DGV)PGC [DGVbeta]
DECIPHERPGC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPGC 
Mutations
ICGC Data PortalPGC 
TCGA Data PortalPGC 
Broad Tumor PortalPGC
OASIS PortalPGC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPGC  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPGC
Mutations and Diseases : HGMDPGC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PGC
DgiDB (Drug Gene Interaction Database)PGC
DoCM (Curated mutations)PGC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PGC (select a term)
intoGenPGC
Cancer3DPGC(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM169740   
Orphanet
DisGeNETPGC
MedgenPGC
Genetic Testing Registry PGC
NextProtP20142 [Medical]
GENETestsPGC
Target ValidationPGC
Huge Navigator PGC [HugePedia]
ClinGenPGC
Clinical trials, drugs, therapy
MyCancerGenomePGC
Protein Interactions : CTD
Pharm GKB GenePA33228
PharosP20142
Clinical trialPGC
Miscellaneous
canSAR (ICR)PGC (select the gene name)
HarmonizomePGC
DataMed IndexPGC
Probes
Litterature
PubMed75 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPGC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:31:09 CET 2021
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