PGLYRP1 (peptidoglycan recognition protein 1)

2009-11-01  

Identity

HGNC
PGLYRP1
LOCATION
19q13.32
LOCUSID
8993
ALIAS
PGLYRP,PGRP,PGRP-S,PGRPS,TAG7,TNFSF3L

Other Information

Locus ID:

NCBI: 8993
MIM: 604963
HGNC: 8904
Ensembl: ENSG00000008438

Variants:

dbSNP: 8993
ClinVar: 8993
TCGA: ENSG00000008438
COSMIC: PGLYRP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000008438ENST00000008938O75594

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Antimicrobial peptidesREACTOMER-HSA-6803157
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
145062762003Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase.62
155724502004Structural basis for peptidoglycan binding by peptidoglycan recognition proteins.41
255957742015Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1.38
159562762005Human peptidoglycan recognition protein S is an effector of neutrophil-mediated innate immunity.33
219847012011Convergent and divergent development among M cell lineages in mouse mucosal epithelium.24
157694622005Crystal structure of human peptidoglycan recognition protein S (PGRP-S) at 1.70 A resolution.22
151408872004Crystal structure of the C-terminal peptidoglycan-binding domain of human peptidoglycan recognition protein Ialpha.17
145858452004Peptidoglycan recognition protein tag7 forms a cytotoxic complex with heat shock protein 70 in solution and in lymphocytes.16
186438452009Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.16

Citation

Dessen P

PGLYRP1 (peptidoglycan recognition protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-11-01

Online version: http://atlasgeneticsoncology.org/gene/51175/pglyrp1