PGLYRP2 (peptidoglycan recognition protein 2)

2014-11-01  

Identity

HGNC
PGLYRP2
LOCATION
19p13.12
LOCUSID
114770
ALIAS
HMFT0141,PGLYRPL,PGRP-L,PGRPL,TAGL-like,tagL,tagL-alpha,tagl-beta

Other Information

Locus ID:

NCBI: 114770
MIM: 608199
HGNC: 30013
Ensembl: ENSG00000161031

Variants:

dbSNP: 114770
ClinVar: 114770
TCGA: ENSG00000161031
COSMIC: PGLYRP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161031ENST00000292609Q96PD5
ENSG00000161031ENST00000340880Q96PD5
ENSG00000161031ENST00000594637M0QYW3
ENSG00000161031ENST00000601792M0R2W8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Antimicrobial peptidesREACTOMER-HSA-6803157

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
179751192008Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.65
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
160544492005Identification of serum N-acetylmuramoyl-l-alanine amidase as liver peptidoglycan recognition protein 2.21
162395162005Peptidoglycan recognition protein 2 (N-acetylmuramoyl-L-Ala amidase) is induced in keratinocytes by bacteria through the p38 kinase pathway.17
190230992009Gene variants associated with ischemic stroke: the cardiovascular health study.16
167142902006Differential expression of peptidoglycan recognition protein 2 in the skin and liver requires different transcription factors.15
248381822014Peptidoglycan recognition protein genes and risk of Parkinson's disease.10
260390762015A Novel Innate Response of Human Corneal Epithelium to Heat-killed Candida albicans by Producing Peptidoglycan Recognition Proteins.7
186493582008Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.6
299149272018Regulation of the Peptidoglycan Amidase PGLYRP2 in Epithelial Cells by Interleukin-36γ.3

Citation

Dessen P

PGLYRP2 (peptidoglycan recognition protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71864/pglyrp2