PGP (phosphoglycolate phosphatase)

2009-03-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
AUM,G3PP,PGPase
FUSION GENES

Other Information

Locus ID:

NCBI: 283871
MIM: 172280
HGNC: 8909
Ensembl: ENSG00000184207

Variants:

dbSNP: 283871
ClinVar: 283871
TCGA: ENSG00000184207
COSMIC: PGP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184207ENST00000333503A6NDG6
ENSG00000184207ENST00000562001H3BV17

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Glyoxylate and dicarboxylate metabolismKEGGko00630
Glyoxylate and dicarboxylate metabolismKEGGhsa00630
Metabolic pathwaysKEGGhsa01100
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
152609172004Pharmacokinetic interactions of drugs with St John's wort.29
186407172009PI3K/Akt inhibition modulates multidrug resistance and activates NF-kappaB in murine lymphoma cell lines.24
161606202005Polymorphic variations in GSTM1, GSTT1, PgP, CYP2D6, CYP3A5, and dopamine D2 and D3 receptors and their association with tardive dyskinesia in severe mental illness.15
156613992005P-glycoprotein is implicated in the inhibition of ceramide-induced apoptosis in TF-1 acute myeloid leukemia cells by modulation of the glucosylceramide synthase pathway.7
170388832006The relationship between P-glycoprotein (PGP) polymorphisms and response to olanzapine treatment in schizophrenia.0
200914102010Cutaneous PGP 9.5 distribution patterns in hidradenitis suppurativa.0
218612062012Association between P-glycoprotein and lymphoid antigen expression on myeloblasts versus therapy response and survival in de novo acute myeloid leukemia: long-term follow-up results.0
257204912015Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp).0
275444412016A Guardian Angel Phosphatase for Mainline Carbon Metabolism.0
295245432018A phosphoglycolate phosphatase/AUM-dependent link between triacylglycerol turnover and epidermal growth factor signaling.0

Citation

Dessen P

PGP (phosphoglycolate phosphatase)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50713/pgp