PGPEP1 (pyroglutamyl-peptidase I)

2007-04-01  

Identity

HGNC
PGPEP1
LOCATION
19p13.11
LOCUSID
54858
ALIAS
PAP-I,PGI,PGP,PGP-I,PGPI,Pcp
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54858
MIM: 610694
HGNC: 13568
Ensembl: ENSG00000130517

Variants:

dbSNP: 54858
ClinVar: 54858
TCGA: ENSG00000130517
COSMIC: PGPEP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130517ENST00000252813Q9NXJ5
ENSG00000130517ENST00000269919Q9NXJ5
ENSG00000130517ENST00000595066U3KQG9
ENSG00000130517ENST00000595552M0R0B6
ENSG00000130517ENST00000596962M0QX66
ENSG00000130517ENST00000597431U3KQ24
ENSG00000130517ENST00000597663M0R3H3
ENSG00000130517ENST00000600283M0QX66
ENSG00000130517ENST00000604499S4R2Y9

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
150140372004VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein.37
126511142003Pyroglutamyl-peptidase I: cloning, sequencing, and characterisation of the recombinant human enzyme.5
256876772015Serum pyroglutamyl aminopeptidase activity: a promising novel biomarker candidate for liver cirrhosis.2
260787062015Altered Activity and Expression of Cytosolic Peptidases in Colorectal Cancer.2
153809242004Pyroglutamyl peptidase I and prolyl endopeptidase in human semen: increased activity in necrozoospermia.1

Citation

Dessen P

PGPEP1 (pyroglutamyl-peptidase I)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46666/pgpep1