PGRMC2 (progesterone receptor membrane component 2)

2013-08-01  

Identity

HGNC
LOCATION
4q28.2
LOCUSID
ALIAS
DG6,PMBP
FUSION GENES

Other Information

Locus ID:

NCBI: 10424
MIM: 607735
HGNC: 16089
Ensembl: ENSG00000164040

Variants:

dbSNP: 10424
ClinVar: 10424
TCGA: ENSG00000164040
COSMIC: PGRMC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164040ENST00000296425O15173
ENSG00000164040ENST00000394276D3DNX8
ENSG00000164040ENST00000503588U3KQM0
ENSG00000164040ENST00000503872D3DNX8
ENSG00000164040ENST00000509070U3KQ70
ENSG00000164040ENST00000512483D3DNX8
ENSG00000164040ENST00000520121O15173
ENSG00000164040ENST00000613358O15173

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
188187482008Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.31
195275142009Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.31
190193352009Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.26
208197782010MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.21
157024322005Classic and non-classic progesterone receptors are both expressed in human spermatozoa.17
201402622010Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.15
232766312013PGRMC2, a yet uncharacterized protein with potential as tumor suppressor, migration inhibitor, and regulator of cytochrome P450 enzyme activity.15
230640062012In vitro inhibition of SKOV-3 cell migration as a distinctive feature of progesterone receptor membrane component type 2 versus type 1.14
317487412019PGRMC2 is an intracellular haem chaperone critical for adipocyte function.9
237934722014Expression patterns of progesterone receptor membrane components 1 and 2 in endometria from women with and without endometriosis.8

Citation

Dessen P

PGRMC2 (progesterone receptor membrane component 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-08-01

Online version: http://atlasgeneticsoncology.org/gene/53736/pgrmc2