PHC3 (polyhomeotic homolog 3)

2007-04-01  

Identity

HGNC
LOCATION
3q26.2
LOCUSID
ALIAS
EDR3,HPH3
FUSION GENES

Other Information

Locus ID:

NCBI: 80012
HGNC: 15682
Ensembl: ENSG00000173889

Variants:

dbSNP: 80012
ClinVar: 80012
TCGA: ENSG00000173889
COSMIC: PHC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173889ENST00000466189C9J6H0
ENSG00000173889ENST00000467570E7EX82
ENSG00000173889ENST00000472330F8WDA4
ENSG00000173889ENST00000475729C9JYH7
ENSG00000173889ENST00000479467B4DTC4
ENSG00000173889ENST00000481639G5E9U7
ENSG00000173889ENST00000484068H7C528
ENSG00000173889ENST00000484931C9JAU4
ENSG00000173889ENST00000486042H7C4H9
ENSG00000173889ENST00000494943Q8NDX5
ENSG00000173889ENST00000495893Q8NDX5
ENSG00000173889ENST00000497658Q8NDX5

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580
SUMOylation of RNA binding proteinsREACTOMER-HSA-4570464

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
170013162007PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors.18
204917732010Polycomb group molecule PHC3 regulates polycomb complex composition and prognosis of osteosarcoma.9
263433562015Polycomb genes are associated with response to imatinib in chronic myeloid leukemia.8
227244432012Human polyhomeotic homolog 3 (PHC3) sterile alpha motif (SAM) linker allows open-ended polymerization of PHC3 SAM.2
239420792013Mutational analysis of Polycomb genes in solid tumours identifies PHC3 amplification as a possible cancer-driving genetic alteration.2

Citation

Dessen P

PHC3 (polyhomeotic homolog 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47433/phc3