Identity
HGNC
LOCATION
6p21.32
LOCUSID
ALIAS
MTF2L2,PCL1,PHF2,TDRD19C,hPHF1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5252
MIM: 602881
HGNC: 8919
Ensembl: ENSG00000112511
Variants:
dbSNP: 5252
ClinVar: 5252
TCGA: ENSG00000112511
COSMIC: PHF1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Gene Expression | REACTOME | R-HSA-74160 |
| Epigenetic regulation of gene expression | REACTOME | R-HSA-212165 |
| PRC2 methylates histones and DNA | REACTOME | R-HSA-212300 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37819540 | 2024 | When molecular outsmarts morphology: Malignant ossifying fibromyxoid tumors masquerading as osteosarcomas, including a novel CREBZF::PHF1 fusion. | 0 |
| 37819540 | 2024 | When molecular outsmarts morphology: Malignant ossifying fibromyxoid tumors masquerading as osteosarcomas, including a novel CREBZF::PHF1 fusion. | 0 |
| 34560087 | 2021 | A PHF1-TFE3 fusion atypical ossifying fibromyxoid tumor with prominent collagenous rosettes: Case report with a brief review. | 1 |
| 34560087 | 2021 | A PHF1-TFE3 fusion atypical ossifying fibromyxoid tumor with prominent collagenous rosettes: Case report with a brief review. | 1 |
| 31932680 | 2020 | PHF1 fusions cause distinct gene expression and chromatin accessibility profiles in ossifying fibromyxoid tumors and mesenchymal cells. | 12 |
| 32237188 | 2020 | A novel MBTD1-PHF1 gene fusion in endometrial stromal sarcoma: A case report and literature review. | 9 |
| 33179613 | 2020 | Primary malignant ossifying fibromyxoid tumour of the bone. A clinicopathologic and molecular report of two cases. | 1 |
| 31932680 | 2020 | PHF1 fusions cause distinct gene expression and chromatin accessibility profiles in ossifying fibromyxoid tumors and mesenchymal cells. | 12 |
| 32237188 | 2020 | A novel MBTD1-PHF1 gene fusion in endometrial stromal sarcoma: A case report and literature review. | 9 |
| 33179613 | 2020 | Primary malignant ossifying fibromyxoid tumour of the bone. A clinicopathologic and molecular report of two cases. | 1 |
| 29846670 | 2018 | PHD finger protein 1 (PHF1) is a novel reader for histone H4R3 symmetric dimethylation and coordinates with PRMT5-WDR77/CRL4B complex to promote tumorigenesis. | 43 |
| 29846670 | 2018 | PHD finger protein 1 (PHF1) is a novel reader for histone H4R3 symmetric dimethylation and coordinates with PRMT5-WDR77/CRL4B complex to promote tumorigenesis. | 43 |
| 28082396 | 2017 | PHF1 Tudor and N-terminal domains synergistically target partially unwrapped nucleosomes to increase DNA accessibility. | 18 |
| 28082396 | 2017 | PHF1 Tudor and N-terminal domains synergistically target partially unwrapped nucleosomes to increase DNA accessibility. | 18 |
| 25923537 | 2015 | An aromatic cage is required but not sufficient for binding of Tudor domains of the Polycomblike protein family to H3K36me3. | 13 |
Citation
Dessen P
PHF1 (PHD finger protein 1)
Atlas Genet Cytogenet Oncol Haematol. 2006-08-01
Online version: http://atlasgeneticsoncology.org/gene/42976/phf1
