PHF19 (PHD finger protein 19)

2007-02-01  

Identity

HGNC
PHF19
LOCATION
9q33.2
LOCUSID
26147
ALIAS
MTF2L1,PCL3,TDRD19B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26147
MIM: 609740
HGNC: 24566
Ensembl: ENSG00000119403

Variants:

dbSNP: 26147
ClinVar: 26147
TCGA: ENSG00000119403
COSMIC: PHF19

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119403ENST00000312189Q5T6S3
ENSG00000119403ENST00000373896Q5T6S3
ENSG00000119403ENST00000419155F5H8K3
ENSG00000119403ENST00000436309B0QZ72
ENSG00000119403ENST00000439674B0QZ51
ENSG00000119403ENST00000453868B0QZ50
ENSG00000119403ENST00000456291X6RER8
ENSG00000119403ENST00000616568A0A087X169

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
PRC2 methylates histones and DNAREACTOMER-HSA-212300

References

Pubmed IDYearTitleCitations
231603512012Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation.79
155638322004A novel human homologue of Drosophila polycomblike gene is up-regulated in multiple cancers.43
232286622013Tudor domains of the PRC2 components PHF1 and PHF19 selectively bind to histone H3K36me3.16
266880702015G9a orchestrates PCL3 and KDM7A to promote histone H3K27 methylation.14
211431972011Functional characterization of human Polycomb-like 3 isoforms identifies them as components of distinct EZH2 protein complexes.13
224876812012PHF19 and Akt control the switch between proliferative and invasive states in melanoma.13
259553882015MicroRNA-195-5p acts as an anti-oncogene by targeting PHF19 in hepatocellular carcinoma.13
294830962018hPCL3s Promotes Hepatocellular Carcinoma Metastasis by Activating β-Catenin Signaling.8
301312502018microRNA-124a suppresses PHF19 over-expression, EZH2 hyper-activation, and aberrant cell proliferation in human glioma.6
303232242018PHF19 promotes the proliferation, migration, and chemosensitivity of glioblastoma to doxorubicin through modulation of the SIAH1/β-catenin axis.6

Citation

Dessen P

PHF19 (PHD finger protein 19)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46423/phf19