PHF20L1 (PHD finger protein 20 like 1)

2012-11-01  

Identity

HGNC
LOCATION
8q24.22
LOCUSID
ALIAS
CGI-72,TDRD20B,URLC1
FUSION GENES

Other Information

Locus ID:

NCBI: 51105
HGNC: 24280
Ensembl: ENSG00000129292

Variants:

dbSNP: 51105
ClinVar: 51105
TCGA: ENSG00000129292
COSMIC: PHF20L1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129292ENST00000220847A0A0A0MQS0
ENSG00000129292ENST00000337920A8MW92
ENSG00000129292ENST00000395376A8MXR8
ENSG00000129292ENST00000395379A8MUE8
ENSG00000129292ENST00000395386A8MW92
ENSG00000129292ENST00000395390F8W9L8
ENSG00000129292ENST00000460236H0YDF7
ENSG00000129292ENST00000485595A0A0D9SG14
ENSG00000129292ENST00000486199E9PM57
ENSG00000129292ENST00000521038H0YC05
ENSG00000129292ENST00000522580E5RK91
ENSG00000129292ENST00000622263A8MW92

Expression (GTEx)

0
5
10
15
20
25
30

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
244926122014Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation.13
265888622016An integrated genomic analysis of Tudor domain-containing proteins identifies PHD finger protein 20-like 1 (PHF20L1) as a candidate oncogene in breast cancer.13
293583312018LSD1 demethylase and the methyl-binding protein PHF20L1 prevent SET7 methyltransferase-dependent proteolysis of the stem-cell protein SOX2.6
288412142017Tudor-domain protein PHF20L1 reads lysine methylated retinoblastoma tumour suppressor protein.4
300898522018PHF20L1 antagonizes SOX2 proteolysis triggered by the MLL1/WDR5 complexes.2

Citation

Dessen P

PHF20L1 (PHD finger protein 20 like 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-11-01

Online version: http://atlasgeneticsoncology.org/gene/53032/phf20l1