PHLDB2 (pleckstrin homology like domain family B member 2)

2010-07-01  

Identity

HGNC
PHLDB2
LOCATION
3q13.2
LOCUSID
90102
ALIAS
LL5b,LL5beta
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 90102
MIM: 610298
HGNC: 29573
Ensembl: ENSG00000144824

Variants:

dbSNP: 90102
ClinVar: 90102
TCGA: ENSG00000144824
COSMIC: PHLDB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144824ENST00000393923Q86SQ0
ENSG00000144824ENST00000393925Q86SQ0
ENSG00000144824ENST00000412622Q86SQ0
ENSG00000144824ENST00000431670Q86SQ0
ENSG00000144824ENST00000477695G5E9V3
ENSG00000144824ENST00000478733A0A1W2PQ63
ENSG00000144824ENST00000478922E9PDY7
ENSG00000144824ENST00000481953Q86SQ0
ENSG00000144824ENST00000495180E9PGF6
ENSG00000144824ENST00000498699E9PFQ4
ENSG00000144824ENST00000638331A0A1W2PRT1
ENSG00000144824ENST00000640905A0A1W2PRJ2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
168249502006CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta.130
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
205137692010Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5alpha/beta.26
249824452014Liprin-α1, ERC1 and LL5 define polarized and dynamic structures that are implicated in cell migration.19
235250082013Amotl2 interacts with LL5β, localizes to podosomes and regulates postsynaptic differentiation in muscle.18
283923962017p53 target miR-29c-3p suppresses colon cancer cell invasion and migration through inhibition of PHLDB2.16
273781692016Prickle1 promotes focal adhesion disassembly in cooperation with the CLASP-LL5β complex in migrating cells.10
202369362010LL5beta directs the translocation of filamin A and SHIP2 to sites of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulation, and PtdIns(3,4,5)P3 localization is mutually modified by co-recruited SHIP2.9
221116642013Functions of intronic nucleotide variants in the gene encoding pleckstrin homology like domain beta 2 (PHLDB2) on susceptibility to vascular dementia.2

Citation

Dessen P

PHLDB2 (pleckstrin homology like domain family B member 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-07-01

Online version: http://atlasgeneticsoncology.org/gene/51562/phldb2