PI16 (peptidase inhibitor 16)

2007-02-01  

Identity

HGNC
PI16
LOCATION
6p21.2
LOCUSID
221476
ALIAS
CD364,CRISP9,MSMBBP,PSPBP

Other Information

Locus ID:

NCBI: 221476
HGNC: 21245
Ensembl: ENSG00000164530

Variants:

dbSNP: 221476
ClinVar: 221476
TCGA: ENSG00000164530
COSMIC: PI16

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164530ENST00000373674Q6UXB8
ENSG00000164530ENST00000611814Q6UXB8
ENSG00000164530ENST00000647861Q6UXB8

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
retina
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
170626752006Prognostic value of prostate secretory protein of 94 amino acids and its binding protein after radical prostatectomy.30
153449092005Identification, purification and characterization of a novel human blood protein with binding affinity for prostate secretory protein of 94 amino acids.13
279960452016PI16 is a shear stress and inflammation-regulated inhibitor of MMP2.8
225339722012PI16 is expressed by a subset of human memory Treg with enhanced migration to CCL17 and CCL20.6
303651572018Skin-homing CD8+ T cells preferentially express GPI-anchored peptidase inhibitor 16, an inhibitor of cathepsin K.2
311278572019Peptidase inhibitor 16 identifies a human regulatory T-cell subset with reduced FOXP3 expression over the first year of recent onset type 1 diabetes.0

Citation

Dessen P

PI16 (peptidase inhibitor 16)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45592/pi16