PI4KA (phosphatidylinositol 4-kinase alpha)

2014-09-01  

Identity

HGNC
LOCATION
22q11.21
LOCUSID
ALIAS
PI4K-ALPHA,PIK4CA,PMGYCHA,pi4K230
FUSION GENES

Other Information

Locus ID:

NCBI: 5297
MIM: 600286
HGNC: 8983
Ensembl: ENSG00000241973

Variants:

dbSNP: 5297
ClinVar: 5297
TCGA: ENSG00000241973
COSMIC: PI4KA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000241973ENST00000255882P42356
ENSG00000241973ENST00000399213A8MTF1
ENSG00000241973ENST00000449120C9JLI1

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Inositol phosphate metabolismKEGGko00562
Phosphatidylinositol signaling systemKEGGko04070
Inositol phosphate metabolismKEGGhsa00562
Phosphatidylinositol signaling systemKEGGhsa04070
Metabolic pathwaysKEGGhsa01100
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4KEGGhsa_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4KEGGM00130
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255
Synthesis of PIPs at the ER membraneREACTOMER-HSA-1483248
Synthesis of PIPs at the Golgi membraneREACTOMER-HSA-1660514

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
212389452011Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment.237
196054712009Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication.105
216974872011Hepatitis C virus stimulates the phosphatidylinositol 4-kinase III alpha-dependent phosphatidylinositol 4-phosphate production that is essential for its replication.88
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
193043082009Identification of a lipid kinase as a host factor involved in hepatitis C virus RNA replication.84
180775552008Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha.80
196086262009Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening.78
236753032013The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A.60
156346692005Distinct Golgi populations of phosphatidylinositol 4-phosphate regulated by phosphatidylinositol 4-kinases.53
212971622011Hepatitis C virus NS5A protein interacts with phosphatidylinositol 4-kinase type IIIalpha and regulates viral propagation.47

Citation

Dessen P

PI4KA (phosphatidylinositol 4-kinase alpha)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54852/pi4ka