Identity
HGNC
LOCATION
18q12.3
LOCUSID
ALIAS
VPS34,Vps34,hVps34
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5289
MIM: 602609
HGNC: 8974
Ensembl: ENSG00000078142
Variants:
dbSNP: 5289
ClinVar: 5289
TCGA: ENSG00000078142
COSMIC: PIK3C3
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36629752 | 2023 | PIK3C3/VPS34 keeps body fats healthy. | 0 |
| 36656016 | 2023 | Listeria InlB Expedites Vacuole Escape and Intracellular Proliferation by Promoting Rab7 Recruitment via Vps34. | 1 |
| 37267363 | 2023 | ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation. | 9 |
| 36629752 | 2023 | PIK3C3/VPS34 keeps body fats healthy. | 0 |
| 36656016 | 2023 | Listeria InlB Expedites Vacuole Escape and Intracellular Proliferation by Promoting Rab7 Recruitment via Vps34. | 1 |
| 37267363 | 2023 | ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation. | 9 |
| 34870550 | 2022 | Adaptor SH3BGRL drives autophagy-mediated chemoresistance through promoting PIK3C3 translation and ATG12 stability in breast cancers. | 6 |
| 35333349 | 2022 | Overcoming radio-resistance in esophageal squamous cell carcinoma via hypermethylation of PIK3C3 promoter region mediated by KDM5B loss. | 2 |
| 34870550 | 2022 | Adaptor SH3BGRL drives autophagy-mediated chemoresistance through promoting PIK3C3 translation and ATG12 stability in breast cancers. | 6 |
| 35333349 | 2022 | Overcoming radio-resistance in esophageal squamous cell carcinoma via hypermethylation of PIK3C3 promoter region mediated by KDM5B loss. | 2 |
| 32248620 | 2021 | The Warburg Micro Syndrome-associated Rab3GAP-Rab18 module promotes autolysosome maturation through the Vps34 Complex I. | 12 |
| 33400087 | 2021 | Targeting the Autophagy Specific Lipid Kinase VPS34 for Cancer Treatment: An Integrative Repurposing Strategy. | 1 |
| 33637724 | 2021 | VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism. | 26 |
| 33664238 | 2021 | SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer. | 41 |
| 33692360 | 2021 | Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes. | 31 |
Citation
Dessen P
PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/41714/pik3c3
