PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)

2003-02-01 Affiliation

Identity

HGNC

PIK3CG

LOCATION

7q22.3

LOCUSID

5294

ALIAS

PI3CG,PI3K,PI3Kgamma,PIK3,p110gamma,p120-PI3K

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5294
MIM: 601232
HGNC: 8978
Ensembl: ENSG00000105851

Variants:

dbSNP: 5294
ClinVar: 5294
TCGA: ENSG00000105851
COSMIC: PIK3CG

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000105851	ENST00000359195	P48736
ENSG00000105851	ENST00000359195	A0A024R720
ENSG00000105851	ENST00000440650	P48736
ENSG00000105851	ENST00000440650	A0A024R720
ENSG00000105851	ENST00000473541	E9PDN7
ENSG00000105851	ENST00000496166	P48736
ENSG00000105851	ENST00000496166	A0A024R720

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Inositol phosphate metabolism	KEGG	ko00562
Inositol phosphate metabolism	KEGG	hsa00562
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Cholinergic synapse	KEGG	hsa04725
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Adrenergic signaling in cardiomyocytes	KEGG	hsa04261
Adrenergic signaling in cardiomyocytes	KEGG	ko04261
Platelet activation	KEGG	hsa04611
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
GPVI-mediated activation cascade	REACTOME	R-HSA-114604
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G-protein beta:gamma signalling	REACTOME	R-HSA-397795
G beta:gamma signalling through PI3Kgamma	REACTOME	R-HSA-392451
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Phospholipid metabolism	REACTOME	R-HSA-1483257
PI Metabolism	REACTOME	R-HSA-1483255
Synthesis of PIPs at the plasma membrane	REACTOME	R-HSA-1660499
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072
Apelin signaling pathway	KEGG	hsa04371

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA24684	AKT1	Gene	Pathway	associated	28362716
PA27844	ERBB2	Gene	Pathway	associated
PA27846	ERBB3	Gene	Pathway	associated
PA27847	ERBB4	Gene	Pathway	associated
PA28180	FLT1	Gene	Pathway	associated	28362716
PA28183	FLT4	Gene	Pathway	associated	28362716
PA30086	KDR	Gene	Pathway	associated	28362716
PA7360	EGFR	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
19567590	2009	In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models.	219
18725974	2008	Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.	138
17290298	2007	PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?	131
21665146	2011	Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.	116
16432180	2006	Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase.	106
17173040	2007	PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis.	103
17551921	2007	Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion.	102
20375364	2010	Airway PI3K pathway activation is an early and reversible event in lung cancer development.	98
20627085	2010	A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions.	95
20622047	2010	PI(3)king apart PTEN's role in cancer.	90

Citation

Dessen P

PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41716/pik3cg