PIM2 (Pim-2 proto-oncogene, serine/threonine kinase)

2003-02-01  

Identity

HGNC
LOCATION
Xp11.23
LOCUSID
FUSION GENES

Other Information

Locus ID:

NCBI: 11040
MIM: 300295
HGNC: 8987
Ensembl: ENSG00000102096

Variants:

dbSNP: 11040
ClinVar: 11040
TCGA: ENSG00000102096
COSMIC: PIM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102096ENST00000376509Q9P1W9
ENSG00000102096ENST00000376509A0A024QYW7
ENSG00000102096ENST00000442430C9J8V9

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Acute myeloid leukemiaKEGGko05221
Acute myeloid leukemiaKEGGhsa05221

References

Pubmed IDYearTitleCitations
185939062008Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels.109
129546152003The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death.88
184246972008Cutting edge: Foxp3-mediated induction of pim 2 allows human T regulatory cells to preferentially expand in rapamycin.67
164032192006Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL.61
218598462011Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma.61
238185472013Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation.59
182162972008The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes.55
152913542004Increased expression of the hPim-2 gene in human chronic lymphocytic leukemia and non-Hodgkin lymphoma.44
214752532011The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells.34
160155932005Pim-2 upregulation: biological implications associated with disease progression and perinueral invasion in prostate cancer.32

Citation

Dessen P

PIM2 (Pim-2 proto-oncogene, serine/threonine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41718/pim2