PIP (prolactin induced protein)

2007-02-01 Affiliation

Identity

HGNC

PIP

LOCATION

7q34

LOCUSID

5304

ALIAS

GCDFP-15,GCDFP15,GPIP4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5304
MIM: 176720
HGNC: 8993
Ensembl: ENSG00000159763

Variants:

dbSNP: 5304
ClinVar: 5304
TCGA: ENSG00000159763
COSMIC: PIP

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000159763	ENST00000291009	P12273

Expression (GTEx)

5000

10000

15000

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
Miscellaneous transport and binding events	REACTOME	R-HSA-5223345

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
21809344	2012	Runx2 controls a feed-forward loop between androgen and prolactin-induced protein (PIP) in stimulating T47D cell proliferation.	29
24114735	2014	Additive effect of the AZGP1, PIP, S100A8 and UBE2C molecular biomarkers improves outcome prediction in breast carcinoma.	27
23663520	2013	Molecular apocrine breast cancers are aggressive estrogen receptor negative tumors overexpressing either HER2 or GCDFP15.	22
10713110	2000	A novel aspartyl proteinase from apocrine epithelia and breast tumors.	19
25405607	2014	Gross cystic disease fluid protein-15/prolactin-inducible protein as a biomarker for keratoconus disease.	19
18930737	2008	Crystal structure of the novel complex formed between zinc alpha2-glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma.	18
23332923	2013	Expression of mammaglobin and gross cystic disease fluid protein-15 in breast carcinomas.	16
15632136	2005	GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol.	15
18251583	2008	Analysis of expression patterns of breast cancer-specific markers (mammaglobin and gross cystic disease fluid protein 15) in lung and pleural tumors.	15
19650845	2010	CLC- a novel susceptibility gene for allergic rhinitis?	14

Citation

Dessen P

PIP (prolactin induced protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45702/pip