PKIB (cAMP-dependent protein kinase inhibitor beta)

2003-02-01  

Identity

HGNC
PKIB
LOCATION
6q22.31
LOCUSID
5570
ALIAS
PRKACN2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5570
MIM: 606914
HGNC: 9018
Ensembl: ENSG00000135549

Variants:

dbSNP: 5570
ClinVar: 5570
TCGA: ENSG00000135549
COSMIC: PKIB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135549ENST00000258014Q9C010
ENSG00000135549ENST00000354275Q9C010
ENSG00000135549ENST00000368446Q5T0Z6
ENSG00000135549ENST00000368448Q9C010
ENSG00000135549ENST00000368452Q9C010
ENSG00000135549ENST00000392490Q9C010
ENSG00000135549ENST00000392491Q9C010
ENSG00000135549ENST00000615438Q9C010

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
20526161991Molecular cloning of a rat testis form of the inhibitor protein of cAMP-dependent protein kinase.8
194837212009Overexpressing PKIB in prostate cancer promotes its aggressiveness by linking between PKA and Akt pathways.8
76843691993Evidence for two additional isoforms of the endogenous protein kinase inhibitor of cAMP-dependent protein kinase in mouse.7
248696582014Protein kinase inhibitor β enhances the constitutive activity of G-protein-coupled zinc receptor GPR39.5
120617252002Isolation of novel differentially expressed genes related to human glioma using cDNA microarray and characterizations of two novel full-length genes.4
232246022012PKIB expression strongly correlated with phosphorylated Akt expression in breast cancers and also with triple-negative breast cancer subtype.4
273255572016PKIB promotes cell proliferation and the invasion-metastasis cascade through the PI3K/Akt pathway in NSCLC cells.2
190350912008[Expression and characterizations of a novel full-length gene PKIbeta related to human glioma].1

Citation

Dessen P

PKIB (cAMP-dependent protein kinase inhibitor beta)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41727/pkib