Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1)

Identity

Alias_symbol (synonym)MYT1
PPP1R126
Other alias
HGNC (Hugo) PKMYT1
LocusID (NCBI) 9088
Atlas_Id 43411
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 2972808 and ends at 2980446 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANKRD10 (13q34) / PKMYT1 (16p13.3)PKMYT1 (16p13.3) / CLDN6 (16p13.3)PKMYT1 (16p13.3) / PAQR4 (16p13.3)
PKMYT1 (16p13.3) / TMEM203 (9q34.3)PKMYT1 16p13.3 / CLDN6 16p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  PKMYT1/CLDN6 (16p13)

External links

Nomenclature
HGNC (Hugo)PKMYT1   29650
Cards
Entrez_Gene (NCBI)PKMYT1  9088  protein kinase, membrane associated tyrosine/threonine 1
AliasesMYT1; PPP1R126
GeneCards (Weizmann)PKMYT1
Ensembl hg19 (Hinxton)ENSG00000127564 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000127564 [Gene_View]  ENSG00000127564 [Sequence]  chr16:2972808-2980446 [Contig_View]  PKMYT1 [Vega]
ICGC DataPortalENSG00000127564
TCGA cBioPortalPKMYT1
AceView (NCBI)PKMYT1
Genatlas (Paris)PKMYT1
WikiGenes9088
SOURCE (Princeton)PKMYT1
Genetics Home Reference (NIH)PKMYT1
Genomic and cartography
GoldenPath hg38 (UCSC)PKMYT1  -     chr16:2972808-2980446 -  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PKMYT1  -     16p13.3   [Description]    (hg19-Feb_2009)
GoldenPathPKMYT1 - 16p13.3 [CytoView hg19]  PKMYT1 - 16p13.3 [CytoView hg38]
Genome Data Viewer NCBIPKMYT1 [Mapview hg19]  
OMIM602474   
Gene and transcription
Genbank (Entrez)AK097642 AK098452 AK294379 AK301926 AK303005
RefSeq transcript (Entrez)NM_001258450 NM_001258451 NM_004203 NM_182687
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PKMYT1
Alternative Splicing GalleryENSG00000127564
Gene ExpressionPKMYT1 [ NCBI-GEO ]   PKMYT1 [ EBI - ARRAY_EXPRESS ]   PKMYT1 [ SEEK ]   PKMYT1 [ MEM ]
Gene Expression Viewer (FireBrowse)PKMYT1 [ Firebrowse - Broad ]
GenevisibleExpression of PKMYT1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9088
GTEX Portal (Tissue expression)PKMYT1
Human Protein AtlasENSG00000127564-PKMYT1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99640   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99640  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99640
Splice isoforms : SwissVarQ99640
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ99640
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS    Tyr/Thr_kinase_Cdc2_inhib   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)PKMYT1
DMDM Disease mutations9088
PDB (RSDB)3P1A    5VCV    5VCW    5VCX    5VCY    5VCZ    5VD0    5VD1    5VD3   
PDB Europe3P1A    5VCV    5VCW    5VCX    5VCY    5VCZ    5VD0    5VD1    5VD3   
PDB (PDBSum)3P1A    5VCV    5VCW    5VCX    5VCY    5VCZ    5VD0    5VD1    5VD3   
PDB (IMB)3P1A    5VCV    5VCW    5VCX    5VCY    5VCZ    5VD0    5VD1    5VD3   
Structural Biology KnowledgeBase3P1A    5VCV    5VCW    5VCX    5VCY    5VCZ    5VD0    5VD1    5VD3   
SCOP (Structural Classification of Proteins)3P1A    5VCV    5VCW    5VCX    5VCY    5VCZ    5VD0    5VD1    5VD3   
CATH (Classification of proteins structures)3P1A    5VCV    5VCW    5VCX    5VCY    5VCZ    5VD0    5VD1    5VD3   
SuperfamilyQ99640
Human Protein Atlas [tissue]ENSG00000127564-PKMYT1 [tissue]
Peptide AtlasQ99640
HPRD03920
IPIIPI00384765   IPI00939425   IPI00909627   IPI01011697   IPI00377017   
Protein Interaction databases
DIP (DOE-UCLA)Q99640
IntAct (EBI)Q99640
FunCoupENSG00000127564
BioGRIDPKMYT1
STRING (EMBL)PKMYT1
ZODIACPKMYT1
Ontologies - Pathways
QuickGOQ99640
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  G2/M transition of mitotic cell cycle  Golgi membrane  mitotic cell cycle  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  endoplasmic reticulum  endoplasmic reticulum membrane  Golgi apparatus  cytosol  protein phosphorylation  regulation of mitotic nuclear division  negative regulation of phosphatase activity  membrane  kinase activity  kinase activity  metal ion binding  meiotic cell cycle  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  G2/M transition of mitotic cell cycle  Golgi membrane  mitotic cell cycle  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  endoplasmic reticulum  endoplasmic reticulum membrane  Golgi apparatus  cytosol  protein phosphorylation  regulation of mitotic nuclear division  negative regulation of phosphatase activity  membrane  kinase activity  kinase activity  metal ion binding  meiotic cell cycle  
Pathways : KEGGCell cycle    Oocyte meiosis    Progesterone-mediated oocyte maturation   
NDEx NetworkPKMYT1
Atlas of Cancer Signalling NetworkPKMYT1
Wikipedia pathwaysPKMYT1
Orthology - Evolution
OrthoDB9088
GeneTree (enSembl)ENSG00000127564
Phylogenetic Trees/Animal Genes : TreeFamPKMYT1
HOGENOMQ99640
Homologs : HomoloGenePKMYT1
Homology/Alignments : Family Browser (UCSC)PKMYT1
Gene fusions - Rearrangements
Fusion : MitelmanPKMYT1/CLDN6 [16p13.3/16p13.3]  
Fusion PortalPKMYT1 16p13.3 CLDN6 16p13.3 BRCA
Fusion : QuiverPKMYT1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPKMYT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PKMYT1
dbVarPKMYT1
ClinVarPKMYT1
1000_GenomesPKMYT1 
Exome Variant ServerPKMYT1
GNOMAD BrowserENSG00000127564
Varsome BrowserPKMYT1
Genetic variants : HAPMAP9088
Genomic Variants (DGV)PKMYT1 [DGVbeta]
DECIPHERPKMYT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPKMYT1 
Mutations
ICGC Data PortalPKMYT1 
TCGA Data PortalPKMYT1 
Broad Tumor PortalPKMYT1
OASIS PortalPKMYT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPKMYT1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPKMYT1
Mutations and Diseases : HGMDPKMYT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutaselect PKMYT1
DgiDB (Drug Gene Interaction Database)PKMYT1
DoCM (Curated mutations)PKMYT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PKMYT1 (select a term)
intoGenPKMYT1
Cancer3DPKMYT1 (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602474   
Orphanet
DisGeNETPKMYT1
MedgenPKMYT1
Genetic Testing Registry PKMYT1
NextProtQ99640 [Medical]
TSGene9088
GENETestsPKMYT1
Open Targets GeneticsENSG00000127564  [validation]
snp3D : Map Gene to Disease9088
BioCentury BCIQPKMYT1
ClinGenPKMYT1
Clinical trials, drugs, therapy
Protein Interactions : CTD9088
Pharm GKB GenePA385
Clinical trialPKMYT1
Miscellaneous
canSAR (ICR)PKMYT1 (select the gene name)
HarmonizomePKMYT1
DataMed IndexPKMYT1
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePKMYT1
EVEXPKMYT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 11 20:05:17 CEST 2020
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.