Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PKN1 (protein kinase N1)

Identity

Alias_namesPRKCL1
protein kinase C-like 1
Alias_symbol (synonym)DBK
PRK1
PKN
MGC46204
PAK1
Other aliasPAK-1
PKN-ALPHA
HGNC (Hugo) PKN1
LocusID (NCBI) 5585
Atlas_Id 41858
Location 19p13.12  [Link to chromosome band 19p13]
Location_base_pair Starts at 14440274 and ends at 14471867 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANXA4 (2p13.3) / PKN1 (19p13.12)ARL6IP6 (2q23.3) / PKN1 (19p13.12)DHODH (16q22.2) / PKN1 (19p13.12)
GIPC1 (19p13.12) / PKN1 (19p13.12)PKN1 (19p13.12) / ASH1L (1q22)PKN1 (19p13.12) / LDLR (19p13.2)
TECR (19p13.12) / PKN1 (19p13.12)PKN1 19p13.12 / LDLR 19p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  Lung: Translocations in Small Cell Carcinoma
inv(19)(p13p13) GIPC1/PKN1
t(2;19)(p13;p13) ANXA4/PKN1
PKN1/LDLR (19p13)
TECR/PKN1 (19p13)
TECR/PKN1 (19p13)

External links

Nomenclature
HGNC (Hugo)PKN1   9405
Cards
Entrez_Gene (NCBI)PKN1  5585  protein kinase N1
AliasesDBK; PAK-1; PAK1; PKN; 
PKN-ALPHA; PRK1; PRKCL1
GeneCards (Weizmann)PKN1
Ensembl hg19 (Hinxton)ENSG00000123143 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000123143 [Gene_View]  ENSG00000123143 [Sequence]  chr19:14440274-14471867 [Contig_View]  PKN1 [Vega]
ICGC DataPortalENSG00000123143
TCGA cBioPortalPKN1
AceView (NCBI)PKN1
Genatlas (Paris)PKN1
WikiGenes5585
SOURCE (Princeton)PKN1
Genetics Home Reference (NIH)PKN1
Genomic and cartography
GoldenPath hg38 (UCSC)PKN1  -     chr19:14440274-14471867 +  19p13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PKN1  -     19p13.12   [Description]    (hg19-Feb_2009)
GoldenPathPKN1 - 19p13.12 [CytoView hg19]  PKN1 - 19p13.12 [CytoView hg38]
ImmunoBaseENSG00000123143
Mapping of homologs : NCBIPKN1 [Mapview hg19]  PKN1 [Mapview hg38]
OMIM601032   
Gene and transcription
Genbank (Entrez)AK123007 AK292130 AK313886 BC018575 BC040061
RefSeq transcript (Entrez)NM_002741 NM_213560
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PKN1
Cluster EST : UnigeneHs.466044 [ NCBI ]
CGAP (NCI)Hs.466044
Alternative Splicing GalleryENSG00000123143
Gene ExpressionPKN1 [ NCBI-GEO ]   PKN1 [ EBI - ARRAY_EXPRESS ]   PKN1 [ SEEK ]   PKN1 [ MEM ]
Gene Expression Viewer (FireBrowse)PKN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5585
GTEX Portal (Tissue expression)PKN1
Human Protein AtlasENSG00000123143-PKN1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16512   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16512  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16512
Splice isoforms : SwissVarQ16512
PhosPhoSitePlusQ16512
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AGC-kinase_C    C2_PKN    HR1_rho-bd    HR1_rpt_sf    Kinase-like_dom_sf    Pkinase_C    PKN1_HR1_2    PKN_HR1_1    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)HR1 (PF02185)    Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam02185    pfam00069    pfam00433   
Domain families : Smart (EMBL)Hr1 (SM00742)  S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)PKN1
DMDM Disease mutations5585
Blocks (Seattle)PKN1
PDB (RSDB)1CXZ    1URF    2RMK    4NKG    4OTD    4OTG    4OTH    4OTI   
PDB Europe1CXZ    1URF    2RMK    4NKG    4OTD    4OTG    4OTH    4OTI   
PDB (PDBSum)1CXZ    1URF    2RMK    4NKG    4OTD    4OTG    4OTH    4OTI   
PDB (IMB)1CXZ    1URF    2RMK    4NKG    4OTD    4OTG    4OTH    4OTI   
Structural Biology KnowledgeBase1CXZ    1URF    2RMK    4NKG    4OTD    4OTG    4OTH    4OTI   
SCOP (Structural Classification of Proteins)1CXZ    1URF    2RMK    4NKG    4OTD    4OTG    4OTH    4OTI   
CATH (Classification of proteins structures)1CXZ    1URF    2RMK    4NKG    4OTD    4OTG    4OTH    4OTI   
SuperfamilyQ16512
Human Protein Atlas [tissue]ENSG00000123143-PKN1 [tissue]
Peptide AtlasQ16512
HPRD03019
IPIIPI00002803   IPI00412672   IPI00965991   
Protein Interaction databases
DIP (DOE-UCLA)Q16512
IntAct (EBI)Q16512
FunCoupENSG00000123143
BioGRIDPKN1
STRING (EMBL)PKN1
ZODIACPKN1
Ontologies - Pathways
QuickGOQ16512
Ontology : AmiGOB cell homeostasis  B cell apoptotic process  regulation of germinal center formation  regulation of immunoglobulin production  renal system process  chromatin binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein kinase C activity  protein kinase C binding  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  endosome  cytosol  regulation of transcription by RNA polymerase II  regulation of transcription by RNA polymerase II  protein phosphorylation  negative regulation of protein kinase activity  hyperosmotic response  signal transduction  activation of JUN kinase activity  epithelial cell migration  GTP-Rho binding  peptidyl-serine phosphorylation  nuclear receptor transcription coactivator activity  nuclear receptor transcription coactivator activity  midbody  negative regulation of B cell proliferation  cleavage furrow  protein-containing complex  histone kinase activity (H3-T11 specific)  histone H3-T11 phosphorylation  intracellular signal transduction  histone binding  histone deacetylase binding  Rac GTPase binding  spleen development  androgen receptor binding  positive regulation of nucleic acid-templated transcription  regulation of cell motility  
Ontology : EGO-EBIB cell homeostasis  B cell apoptotic process  regulation of germinal center formation  regulation of immunoglobulin production  renal system process  chromatin binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein kinase C activity  protein kinase C binding  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  endosome  cytosol  regulation of transcription by RNA polymerase II  regulation of transcription by RNA polymerase II  protein phosphorylation  negative regulation of protein kinase activity  hyperosmotic response  signal transduction  activation of JUN kinase activity  epithelial cell migration  GTP-Rho binding  peptidyl-serine phosphorylation  nuclear receptor transcription coactivator activity  nuclear receptor transcription coactivator activity  midbody  negative regulation of B cell proliferation  cleavage furrow  protein-containing complex  histone kinase activity (H3-T11 specific)  histone H3-T11 phosphorylation  intracellular signal transduction  histone binding  histone deacetylase binding  Rac GTPase binding  spleen development  androgen receptor binding  positive regulation of nucleic acid-templated transcription  regulation of cell motility  
Pathways : KEGGPI3K-Akt signaling pathway    Salmonella infection   
NDEx NetworkPKN1
Atlas of Cancer Signalling NetworkPKN1
Wikipedia pathwaysPKN1
Orthology - Evolution
OrthoDB5585
GeneTree (enSembl)ENSG00000123143
Phylogenetic Trees/Animal Genes : TreeFamPKN1
HOGENOMQ16512
Homologs : HomoloGenePKN1
Homology/Alignments : Family Browser (UCSC)PKN1
Gene fusions - Rearrangements
Fusion : MitelmanGIPC1/PKN1 [19p13.12/19p13.12]  [inv(19)(p13p13)]  
Fusion : MitelmanPKN1/LDLR [19p13.12/19p13.2]  [t(19;19)(p13;p13)]  
Fusion PortalPKN1 19p13.12 LDLR 19p13.2 BRCA
Fusion : QuiverPKN1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPKN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PKN1
dbVarPKN1
ClinVarPKN1
1000_GenomesPKN1 
Exome Variant ServerPKN1
ExAC (Exome Aggregation Consortium)ENSG00000123143
GNOMAD BrowserENSG00000123143
Varsome BrowserPKN1
Genetic variants : HAPMAP5585
Genomic Variants (DGV)PKN1 [DGVbeta]
DECIPHERPKN1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPKN1 
Mutations
ICGC Data PortalPKN1 
TCGA Data PortalPKN1 
Broad Tumor PortalPKN1
OASIS PortalPKN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPKN1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPKN1
Mutations and Diseases : HGMDPKN1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PKN1
DgiDB (Drug Gene Interaction Database)PKN1
DoCM (Curated mutations)PKN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PKN1 (select a term)
intoGenPKN1
Cancer3DPKN1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601032   
Orphanet
DisGeNETPKN1
MedgenPKN1
Genetic Testing Registry PKN1
NextProtQ16512 [Medical]
TSGene5585
GENETestsPKN1
Target ValidationPKN1
Huge Navigator PKN1 [HugePedia]
snp3D : Map Gene to Disease5585
BioCentury BCIQPKN1
ClinGenPKN1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5585
Chemical/Pharm GKB GenePA33769
Clinical trialPKN1
Miscellaneous
canSAR (ICR)PKN1 (select the gene name)
DataMed IndexPKN1
Probes
Litterature
PubMed104 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePKN1
EVEXPKN1
GoPubMedPKN1
iHOPPKN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 18:01:04 CET 2019
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