PKN2 (protein kinase N2)

2003-11-01  

Identity

HGNC
PKN2
LOCATION
1p22.2
LOCUSID
5586
ALIAS
PAK2,PRK2,PRKCL2,PRO2042,Pak-2,STK7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5586
MIM: 602549
HGNC: 9406
Ensembl: ENSG00000065243

Variants:

dbSNP: 5586
ClinVar: 5586
TCGA: ENSG00000065243
COSMIC: PKN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000065243ENST00000316005B1AL79
ENSG00000065243ENST00000370513Q16513
ENSG00000065243ENST00000370521Q16513
ENSG00000065243ENST00000436111H0Y5V5
ENSG00000065243ENST00000449189H0Y429

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate PKNsREACTOMER-HSA-5625740

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
193808542009Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry.108
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
184432022008Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies.62
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
173327402007Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis.39
198928382010Polymorphisms identified through genome-wide association studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore.37
184373512008Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study).30
217549952011Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration.28
209748042011The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells.24
189786782008Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.21

Citation

Dessen P

PKN2 (protein kinase N2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41859/pkn2