PKNOX2 (PBX/knotted 1 homeobox 2)

2021-06-01  

Identity

HGNC
PKNOX2
LOCATION
11q24.2
LOCUSID
63876
ALIAS
PREP2

Other Information

Locus ID:

NCBI: 63876
MIM: 613066
HGNC: 16714
Ensembl: ENSG00000165495

Variants:

dbSNP: 63876
ClinVar: 63876
TCGA: ENSG00000165495
COSMIC: PKNOX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165495ENST00000298282Q96KN3
ENSG00000165495ENST00000527238E9PKL2
ENSG00000165495ENST00000531212E9PRB6
ENSG00000165495ENST00000532623E9PQS4
ENSG00000165495ENST00000558705H0YLX0

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
212980472011The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.18
115492862001Identification and characterization of human PKNOX2, a novel homeobox-containing gene.11
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
226485092012PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies.6
307455752019PKNOX2 suppresses gastric cancer through the transcriptional activation of IGFBP5 and p53.4
305156932019PKNOX2 expression and regulation in the bone marrow mesenchymal stem cells of Fanconi anemia patients and healthy donors.1

Citation

Dessen P

PKNOX2 (PBX/knotted 1 homeobox 2)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58166/pknox2