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PLA2G10 (phospholipase A2 group X)

Identity

Alias_namesphospholipase A2, group X
Alias_symbol (synonym)GXPLA2
Other aliasGXSPLA2
SPLA2
sPLA2-X
HGNC (Hugo) PLA2G10
LocusID (NCBI) 8399
Atlas_Id 46060
Location 16p13.12  [Link to chromosome band 16p13]
Location_base_pair Starts at 14672548 and ends at 14694573 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PLA2G10 (16p13.12) / SNX29P2 (16p11.2)SNX29P2 (16p11.2) / PLA2G10 (16p13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PLA2G10   9029
Cards
Entrez_Gene (NCBI)PLA2G10  8399  phospholipase A2 group X
AliasesGXPLA2; GXSPLA2; SPLA2; sPLA2-X
GeneCards (Weizmann)PLA2G10
Ensembl hg19 (Hinxton)ENSG00000069764 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000069764 [Gene_View]  ENSG00000069764 [Sequence]  chr16:14672548-14694573 [Contig_View]  PLA2G10 [Vega]
ICGC DataPortalENSG00000069764
TCGA cBioPortalPLA2G10
AceView (NCBI)PLA2G10
Genatlas (Paris)PLA2G10
WikiGenes8399
SOURCE (Princeton)PLA2G10
Genetics Home Reference (NIH)PLA2G10
Genomic and cartography
GoldenPath hg38 (UCSC)PLA2G10  -     chr16:14672548-14694573 -  16p13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLA2G10  -     16p13.12   [Description]    (hg19-Feb_2009)
GoldenPathPLA2G10 - 16p13.12 [CytoView hg19]  PLA2G10 - 16p13.12 [CytoView hg38]
ImmunoBaseENSG00000069764
Mapping of homologs : NCBIPLA2G10 [Mapview hg19]  PLA2G10 [Mapview hg38]
OMIM603603   
Gene and transcription
Genbank (Entrez)BC069539 BC106731 BC106732 BC111804 BM739473
RefSeq transcript (Entrez)NM_003561
RefSeq genomic (Entrez)NC_000016 NT_187607
Consensus coding sequences : CCDS (NCBI)PLA2G10
Cluster EST : UnigeneHs.567366 [ NCBI ]
CGAP (NCI)Hs.567366
Alternative Splicing GalleryENSG00000069764
Gene ExpressionPLA2G10 [ NCBI-GEO ]   PLA2G10 [ EBI - ARRAY_EXPRESS ]   PLA2G10 [ SEEK ]   PLA2G10 [ MEM ]
Gene Expression Viewer (FireBrowse)PLA2G10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8399
GTEX Portal (Tissue expression)PLA2G10
Human Protein AtlasENSG00000069764-PLA2G10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15496   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15496  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15496
Splice isoforms : SwissVarO15496
Catalytic activity : Enzyme3.1.1.4 [ Enzyme-Expasy ]   3.1.1.43.1.1.4 [ IntEnz-EBI ]   3.1.1.4 [ BRENDA ]   3.1.1.4 [ KEGG ]   
PhosPhoSitePlusO15496
Domaine pattern : Prosite (Expaxy)PA2_ASP (PS00119)    PA2_HIS (PS00118)   
Domains : Interpro (EBI)PLipase_A2    PLipase_A2_Asp_AS    PLipase_A2_dom    PLipase_A2_dom_sf    PLipase_A2_His_AS   
Domain families : Pfam (Sanger)Phospholip_A2_1 (PF00068)   
Domain families : Pfam (NCBI)pfam00068   
Domain families : Smart (EMBL)PA2c (SM00085)  
Conserved Domain (NCBI)PLA2G10
DMDM Disease mutations8399
Blocks (Seattle)PLA2G10
PDB (RSDB)1LE6    1LE7    4UY1    5G3M   
PDB Europe1LE6    1LE7    4UY1    5G3M   
PDB (PDBSum)1LE6    1LE7    4UY1    5G3M   
PDB (IMB)1LE6    1LE7    4UY1    5G3M   
Structural Biology KnowledgeBase1LE6    1LE7    4UY1    5G3M   
SCOP (Structural Classification of Proteins)1LE6    1LE7    4UY1    5G3M   
CATH (Classification of proteins structures)1LE6    1LE7    4UY1    5G3M   
SuperfamilyO15496
Human Protein Atlas [tissue]ENSG00000069764-PLA2G10 [tissue]
Peptide AtlasO15496
HPRD04674
IPIIPI00216471   
Protein Interaction databases
DIP (DOE-UCLA)O15496
IntAct (EBI)O15496
FunCoupENSG00000069764
BioGRIDPLA2G10
STRING (EMBL)PLA2G10
ZODIACPLA2G10
Ontologies - Pathways
QuickGOO15496
Ontology : AmiGOphospholipase activity  phospholipase A2 activity  calcium ion binding  phospholipid binding  extracellular region  extracellular space  phospholipid metabolic process  phosphatidic acid biosynthetic process  axon guidance  positive regulation of macrophage derived foam cell differentiation  positive regulation of lipid storage  lipid catabolic process  arachidonic acid metabolic process  positive regulation of cellular protein metabolic process  positive regulation of prostaglandin secretion  phosphatidylglycerol acyl-chain remodeling  phosphatidylinositol acyl-chain remodeling  phosphatidylserine acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  cholesterol homeostasis  regulation of macrophage activation  negative regulation of DNA-binding transcription factor activity  negative regulation of DNA-binding transcription factor activity  calcium-dependent phospholipase A2 activity  arachidonic acid secretion  lysophospholipid transport  positive regulation of arachidonic acid secretion  negative regulation of cholesterol efflux  phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)  phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)  cellular response to leukemia inhibitory factor  
Ontology : EGO-EBIphospholipase activity  phospholipase A2 activity  calcium ion binding  phospholipid binding  extracellular region  extracellular space  phospholipid metabolic process  phosphatidic acid biosynthetic process  axon guidance  positive regulation of macrophage derived foam cell differentiation  positive regulation of lipid storage  lipid catabolic process  arachidonic acid metabolic process  positive regulation of cellular protein metabolic process  positive regulation of prostaglandin secretion  phosphatidylglycerol acyl-chain remodeling  phosphatidylinositol acyl-chain remodeling  phosphatidylserine acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  cholesterol homeostasis  regulation of macrophage activation  negative regulation of DNA-binding transcription factor activity  negative regulation of DNA-binding transcription factor activity  calcium-dependent phospholipase A2 activity  arachidonic acid secretion  lysophospholipid transport  positive regulation of arachidonic acid secretion  negative regulation of cholesterol efflux  phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)  phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)  cellular response to leukemia inhibitory factor  
Pathways : KEGGGlycerophospholipid metabolism    Ether lipid metabolism    Arachidonic acid metabolism    Linoleic acid metabolism    alpha-Linolenic acid metabolism    Ras signaling pathway    Vascular smooth muscle contraction    Pancreatic secretion    Fat digestion and absorption   
NDEx NetworkPLA2G10
Atlas of Cancer Signalling NetworkPLA2G10
Wikipedia pathwaysPLA2G10
Orthology - Evolution
OrthoDB8399
GeneTree (enSembl)ENSG00000069764
Phylogenetic Trees/Animal Genes : TreeFamPLA2G10
HOGENOMO15496
Homologs : HomoloGenePLA2G10
Homology/Alignments : Family Browser (UCSC)PLA2G10
Gene fusions - Rearrangements
Fusion Cancer (Beijing)PLA2G10 [16p13.12]  -  RUNDC2C [FUSC000770]
Fusion Cancer (Beijing)RUNDC2C [PLA2G10]  -  16p13.12 [FUSC000283]
Fusion : QuiverPLA2G10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLA2G10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLA2G10
dbVarPLA2G10
ClinVarPLA2G10
1000_GenomesPLA2G10 
Exome Variant ServerPLA2G10
ExAC (Exome Aggregation Consortium)ENSG00000069764
GNOMAD BrowserENSG00000069764
Varsome BrowserPLA2G10
Genetic variants : HAPMAP8399
Genomic Variants (DGV)PLA2G10 [DGVbeta]
DECIPHERPLA2G10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLA2G10 
Mutations
ICGC Data PortalPLA2G10 
TCGA Data PortalPLA2G10 
Broad Tumor PortalPLA2G10
OASIS PortalPLA2G10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLA2G10  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPLA2G10
Mutations and Diseases : HGMDPLA2G10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PLA2G10
DgiDB (Drug Gene Interaction Database)PLA2G10
DoCM (Curated mutations)PLA2G10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLA2G10 (select a term)
intoGenPLA2G10
Cancer3DPLA2G10(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603603   
Orphanet
DisGeNETPLA2G10
MedgenPLA2G10
Genetic Testing Registry PLA2G10
NextProtO15496 [Medical]
TSGene8399
GENETestsPLA2G10
Target ValidationPLA2G10
Huge Navigator PLA2G10 [HugePedia]
snp3D : Map Gene to Disease8399
BioCentury BCIQPLA2G10
ClinGenPLA2G10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8399
Chemical/Pharm GKB GenePA33360
Clinical trialPLA2G10
Miscellaneous
canSAR (ICR)PLA2G10 (select the gene name)
DataMed IndexPLA2G10
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLA2G10
EVEXPLA2G10
GoPubMedPLA2G10
iHOPPLA2G10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 18:01:06 CET 2019
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