PLA2G10 (phospholipase A2 group X)

2007-02-01 Affiliation

Identity

HGNC

PLA2G10

LOCATION

16p13.12

LOCUSID

8399

ALIAS

GXPLA2,GXSPLA2,SPLA2,sPLA2-X

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8399
MIM: 603603
HGNC: 9029
Ensembl: ENSG00000069764

Variants:

dbSNP: 8399
ClinVar: 8399
TCGA: ENSG00000069764
COSMIC: PLA2G10

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000069764	ENST00000438167	O15496
ENSG00000069764	ENST00000567462	H3BRW4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glycerophospholipid metabolism	KEGG	ko00564
Ether lipid metabolism	KEGG	ko00565
Arachidonic acid metabolism	KEGG	ko00590
Linoleic acid metabolism	KEGG	ko00591
alpha-Linolenic acid metabolism	KEGG	ko00592
Glycerophospholipid metabolism	KEGG	hsa00564
Ether lipid metabolism	KEGG	hsa00565
Arachidonic acid metabolism	KEGG	hsa00590
Linoleic acid metabolism	KEGG	hsa00591
alpha-Linolenic acid metabolism	KEGG	hsa00592
Vascular smooth muscle contraction	KEGG	hsa04270
Vascular smooth muscle contraction	KEGG	ko04270
Metabolic pathways	KEGG	hsa01100
Pancreatic secretion	KEGG	ko04972
Pancreatic secretion	KEGG	hsa04972
Fat digestion and absorption	KEGG	ko04975
Fat digestion and absorption	KEGG	hsa04975
Ras signaling pathway	KEGG	hsa04014
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Phospholipid metabolism	REACTOME	R-HSA-1483257
Glycerophospholipid biosynthesis	REACTOME	R-HSA-1483206
Synthesis of PA	REACTOME	R-HSA-1483166
Acyl chain remodelling of PE	REACTOME	R-HSA-1482839
Acyl chain remodelling of PC	REACTOME	R-HSA-1482788
Acyl chain remodelling of PS	REACTOME	R-HSA-1482801
Acyl chain remodelling of PI	REACTOME	R-HSA-1482922
Acyl chain remodelling of PG	REACTOME	R-HSA-1482925

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
11741884	2002	Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis.	60
15007070	2004	Arachidonic acid release from mammalian cells transfected with human groups IIA and X secreted phospholipase A(2) occurs predominantly during the secretory process and with the involvement of cytosolic phospholipase A(2)-alpha.	55
20357262	2010	Production of vascular endothelial growth factors from human lung macrophages induced by group IIA and group X secreted phospholipases A2.	39
12021277	2002	Potent modification of low density lipoprotein by group X secretory phospholipase A2 is linked to macrophage foam cell formation.	34
18511424	2008	Macrophage secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology.	29
21255140	2011	Relationship between levels of secreted phospholipase A₂ groups IIA and X in the airways and asthma severity.	28
19336475	2009	Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.	27
14962950	2004	Group V sPLA2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation.	25
20974857	2010	Eosinophil cysteinyl leukotriene synthesis mediated by exogenous secreted phospholipase A2 group X.	20
12161451	2002	Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes.	19

Citation

Dessen P

PLA2G10 (phospholipase A2 group X)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46060/pla2g10