PLA2G12A (phospholipase A2 group XIIA)

2014-11-01  

Identity

HGNC
LOCATION
4q25
LOCUSID
ALIAS
GXII,PLA2G12,ROSSY
FUSION GENES

Other Information

Locus ID:

NCBI: 81579
MIM: 611652
HGNC: 18554
Ensembl: ENSG00000123739

Variants:

dbSNP: 81579
ClinVar: 81579
TCGA: ENSG00000123739
COSMIC: PLA2G12A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123739ENST00000243501Q9BZM1
ENSG00000123739ENST00000243501Q542Y6
ENSG00000123739ENST00000502283A0A0C4DGC6
ENSG00000123739ENST00000507961D6RBP5

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Glycerophospholipid metabolismKEGGko00564
Ether lipid metabolismKEGGko00565
Arachidonic acid metabolismKEGGko00590
Linoleic acid metabolismKEGGko00591
alpha-Linolenic acid metabolismKEGGko00592
Glycerophospholipid metabolismKEGGhsa00564
Ether lipid metabolismKEGGhsa00565
Arachidonic acid metabolismKEGGhsa00590
Linoleic acid metabolismKEGGhsa00591
alpha-Linolenic acid metabolismKEGGhsa00592
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Metabolic pathwaysKEGGhsa01100
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Fat digestion and absorptionKEGGko04975
Fat digestion and absorptionKEGGhsa04975
Ras signaling pathwayKEGGhsa04014
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Synthesis of PAREACTOMER-HSA-1483166
Acyl chain remodelling of PEREACTOMER-HSA-1482839
Acyl chain remodelling of PCREACTOMER-HSA-1482788
Acyl chain remodelling of PSREACTOMER-HSA-1482801
Acyl chain remodelling of PIREACTOMER-HSA-1482922
Acyl chain remodelling of PGREACTOMER-HSA-1482925

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
125221022003Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII).23
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
203320992010A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.8
197732792009Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.6
274340782016Association between PLA2G12A Polymorphisms and Schizophrenia in a Han Chinese Population from Northeast China.2
295277192018Association between PLA2G12A polymorphism and patients with schizophrenia in a southern Chinese Han population.0

Citation

Dessen P

PLA2G12A (phospholipase A2 group XIIA)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71950/pla2g12a