PLA2G1B (phospholipase A2 group IB)

2014-08-01  

Identity

HGNC
LOCATION
12q24.31
LOCUSID
ALIAS
PLA2,PLA2A,PPLA2
FUSION GENES

Other Information

Locus ID:

NCBI: 5319
MIM: 172410
HGNC: 9030
Ensembl: ENSG00000170890

Variants:

dbSNP: 5319
ClinVar: 5319
TCGA: ENSG00000170890
COSMIC: PLA2G1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170890ENST00000308366P04054
ENSG00000170890ENST00000423423Q9BS22
ENSG00000170890ENST00000549767F8W062

Expression (GTEx)

0
5000
10000
15000
20000

Pathways

PathwaySourceExternal ID
Glycerophospholipid metabolismKEGGko00564
Ether lipid metabolismKEGGko00565
Arachidonic acid metabolismKEGGko00590
Linoleic acid metabolismKEGGko00591
alpha-Linolenic acid metabolismKEGGko00592
Glycerophospholipid metabolismKEGGhsa00564
Ether lipid metabolismKEGGhsa00565
Arachidonic acid metabolismKEGGhsa00590
Linoleic acid metabolismKEGGhsa00591
alpha-Linolenic acid metabolismKEGGhsa00592
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Metabolic pathwaysKEGGhsa01100
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Fat digestion and absorptionKEGGko04975
Fat digestion and absorptionKEGGhsa04975
Ras signaling pathwayKEGGhsa04014
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Synthesis of PAREACTOMER-HSA-1483166
Acyl chain remodelling of PEREACTOMER-HSA-1482839
Acyl chain remodelling of PCREACTOMER-HSA-1482788
Acyl chain remodelling of PSREACTOMER-HSA-1482801
Acyl chain remodelling of PIREACTOMER-HSA-1482922
Acyl chain remodelling of PGREACTOMER-HSA-1482925

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
164952212006Effect of arachidonic acid reacylation on leukotriene biosynthesis in human neutrophils stimulated with granulocyte-macrophage colony-stimulating factor and formyl-methionyl-leucyl-phenylalanine.22
152204462004Human cytomegalovirus carries a cell-derived phospholipase A2 required for infectivity.11
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
253355472014sPLA2 IB induces human podocyte apoptosis via the M-type phospholipase A2 receptor.9
192973242009Structural insight into the activation mechanism of human pancreatic prophospholipase A2.8
179816792008MMP production in human fibrosarcoma cells and their invasiveness are regulated by group IB secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2.7
244418702014TNF-α induces cytosolic phospholipase A2 expression via Jak2/PDGFR-dependent Elk-1/p300 activation in human lung epithelial cells.6
127595522003The study of cytosolic phospholipase A2 gene polymorphism in schizophrenia using eye movement disturbances as an endophenotypic marker.5
163920402005Expression and induction of secretory phospholipase A2 group IB in brain.5

Citation

Dessen P

PLA2G1B (phospholipase A2 group IB)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54540/pla2g1b