PLA2G3 (phospholipase A2 group III)

2007-02-01  

Identity

HGNC
LOCATION
22q12.2
LOCUSID
ALIAS
GIII-SPLA2,SPLA2III,sPLA2-III

Other Information

Locus ID:

NCBI: 50487
MIM: 611651
HGNC: 17934
Ensembl: ENSG00000100078

Variants:

dbSNP: 50487
ClinVar: 50487
TCGA: ENSG00000100078
COSMIC: PLA2G3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100078ENST00000215885Q9NZ20

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Glycerophospholipid metabolismKEGGko00564
Ether lipid metabolismKEGGko00565
Arachidonic acid metabolismKEGGko00590
Linoleic acid metabolismKEGGko00591
alpha-Linolenic acid metabolismKEGGko00592
Glycerophospholipid metabolismKEGGhsa00564
Ether lipid metabolismKEGGhsa00565
Arachidonic acid metabolismKEGGhsa00590
Linoleic acid metabolismKEGGhsa00591
alpha-Linolenic acid metabolismKEGGhsa00592
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Metabolic pathwaysKEGGhsa01100
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Fat digestion and absorptionKEGGko04975
Fat digestion and absorptionKEGGhsa04975
Ras signaling pathwayKEGGhsa04014
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Acyl chain remodelling of PEREACTOMER-HSA-1482839
Acyl chain remodelling of PCREACTOMER-HSA-1482788
Acyl chain remodelling of PGREACTOMER-HSA-1482925

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
188017412008Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis.41
252300852014Emerging roles of secreted phospholipase A2 enzymes: the 3rd edition.29
158635012005Cellular distribution, post-translational modification, and tumorigenic potential of human group III secreted phospholipase A(2).27
125221022003Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII).23
193712332009Group III secreted phospholipase A2 transgenic mice spontaneously develop inflammation.19
252862282014Secreted phospholipases A2 in cancer: diverse mechanisms of action.18
178680352008Human group III secreted phospholipase A2 promotes neuronal outgrowth and survival.14
179801672007Human group III phospholipase A2 suppresses adenovirus infection into host cells. Evidence that group III, V and X phospholipase A2s act on distinct cellular phospholipid molecular species.12
209302762010PLA2G3, a gene involved in oxidative stress induced death, is associated with Alzheimer's disease.12
209302762010PLA2G3, a gene involved in oxidative stress induced death, is associated with Alzheimer's disease.12

Citation

Dessen P

PLA2G3 (phospholipase A2 group III)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46392/pla2g3