PLA2G4B (phospholipase A2 group IVB)

2018-07-01 Affiliation

Identity

HGNC

PLA2G4B

LOCATION

15q15.1

LOCUSID

100137049

ALIAS

HsT16992,cPLA2-beta

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 100137049
MIM: 606088
HGNC: 9036
Ensembl: ENSG00000243708

Variants:

dbSNP: 100137049
ClinVar: 100137049
TCGA: ENSG00000243708
COSMIC: PLA2G4B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000243708	ENST00000452633	P0C869
ENSG00000243708	ENST00000458483	P0C869
ENSG00000243708	ENST00000569354	H3BSX5

Expression (GTEx)

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glycerophospholipid metabolism	KEGG	ko00564
Ether lipid metabolism	KEGG	ko00565
Arachidonic acid metabolism	KEGG	ko00590
Linoleic acid metabolism	KEGG	ko00591
alpha-Linolenic acid metabolism	KEGG	ko00592
MAPK signaling pathway	KEGG	ko04010
VEGF signaling pathway	KEGG	ko04370
Fc epsilon RI signaling pathway	KEGG	ko04664
Long-term depression	KEGG	ko04730
GnRH signaling pathway	KEGG	ko04912
Glycerophospholipid metabolism	KEGG	hsa00564
Ether lipid metabolism	KEGG	hsa00565
Arachidonic acid metabolism	KEGG	hsa00590
Linoleic acid metabolism	KEGG	hsa00591
alpha-Linolenic acid metabolism	KEGG	hsa00592
MAPK signaling pathway	KEGG	hsa04010
VEGF signaling pathway	KEGG	hsa04370
Fc epsilon RI signaling pathway	KEGG	hsa04664
Long-term depression	KEGG	hsa04730
GnRH signaling pathway	KEGG	hsa04912
Vascular smooth muscle contraction	KEGG	hsa04270
Vascular smooth muscle contraction	KEGG	ko04270
Fc gamma R-mediated phagocytosis	KEGG	ko04666
Fc gamma R-mediated phagocytosis	KEGG	hsa04666
Metabolic pathways	KEGG	hsa01100
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
Serotonergic synapse	KEGG	hsa04726
Ovarian steroidogenesis	KEGG	hsa04913
Ovarian steroidogenesis	KEGG	ko04913
Ras signaling pathway	KEGG	hsa04014
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
Platelet activation	KEGG	hsa04611
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
Choline metabolism in cancer	KEGG	hsa05231
Choline metabolism in cancer	KEGG	ko05231
Metabolism of proteins	REACTOME	R-HSA-392499
Unfolded Protein Response (UPR)	REACTOME	R-HSA-381119
IRE1alpha activates chaperones	REACTOME	R-HSA-381070
XBP1(S) activates chaperone genes	REACTOME	R-HSA-381038
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Phospholipid metabolism	REACTOME	R-HSA-1483257
Glycerophospholipid biosynthesis	REACTOME	R-HSA-1483206
Synthesis of PA	REACTOME	R-HSA-1483166
Acyl chain remodelling of PE	REACTOME	R-HSA-1482839
Acyl chain remodelling of PC	REACTOME	R-HSA-1482788
Hydrolysis of LPC	REACTOME	R-HSA-1483115
Acyl chain remodelling of PS	REACTOME	R-HSA-1482801
Acyl chain remodelling of PG	REACTOME	R-HSA-1482925
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA33384	PLCB1	Gene	Pathway	associated			20938371
PA33393	PLCG2	Gene	Pathway	associated			20938371

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
20167866	2010	Cooperation of TLR2 with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses.	22
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11
20056178	2010	Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.	5
28030848	2017	A novel read-through transcript JMJD7-PLA2G4B regulates head and neck squamous cell carcinoma cell proliferation and survival.	0

Citation

Dessen P

PLA2G4B (phospholipase A2 group IVB)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57545/pla2g4b