PLA2G4D (phospholipase A2 group IVD)

2014-11-01  

Identity

HGNC
PLA2G4D
LOCATION
15q15.1
LOCUSID
283748
ALIAS
cPLA2delta

Other Information

Locus ID:

NCBI: 283748
MIM: 612864
HGNC: 30038
Ensembl: ENSG00000159337

Variants:

dbSNP: 283748
ClinVar: 283748
TCGA: ENSG00000159337
COSMIC: PLA2G4D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159337ENST00000290472Q86XP0

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycerophospholipid metabolismKEGGko00564
Ether lipid metabolismKEGGko00565
Arachidonic acid metabolismKEGGko00590
Linoleic acid metabolismKEGGko00591
alpha-Linolenic acid metabolismKEGGko00592
MAPK signaling pathwayKEGGko04010
VEGF signaling pathwayKEGGko04370
Fc epsilon RI signaling pathwayKEGGko04664
Long-term depressionKEGGko04730
GnRH signaling pathwayKEGGko04912
Glycerophospholipid metabolismKEGGhsa00564
Ether lipid metabolismKEGGhsa00565
Arachidonic acid metabolismKEGGhsa00590
Linoleic acid metabolismKEGGhsa00591
alpha-Linolenic acid metabolismKEGGhsa00592
MAPK signaling pathwayKEGGhsa04010
VEGF signaling pathwayKEGGhsa04370
Fc epsilon RI signaling pathwayKEGGhsa04664
Long-term depressionKEGGhsa04730
GnRH signaling pathwayKEGGhsa04912
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Metabolic pathwaysKEGGhsa01100
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Serotonergic synapseKEGGhsa04726
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913
Ras signaling pathwayKEGGhsa04014
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Platelet activationKEGGhsa04611
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Synthesis of PAREACTOMER-HSA-1483166
Acyl chain remodelling of PEREACTOMER-HSA-1482839
Acyl chain remodelling of PCREACTOMER-HSA-1482788
Hydrolysis of LPCREACTOMER-HSA-1483115
Acyl chain remodelling of PSREACTOMER-HSA-1482801
Acyl chain remodelling of PIREACTOMER-HSA-1482922
Acyl chain remodelling of PGREACTOMER-HSA-1482925
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
276705922016Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a.45
243494732013Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma.20
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
147095602004Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2delta, induced in psoriatic skin.0
162136962005A family based study of the genetic association between the PLA2G4D gene and schizophrenia.0
186868602008[Study on the genetic association between the polymorphism of cytosolic phospholipase A2 family genes and schizophrenia].0
284404062017Associations of maternal PLA2G4C and PLA2G4D polymorphisms with the risk of spontaneous preterm birth in a Chinese population.0

Citation

Dessen P

PLA2G4D (phospholipase A2 group IVD)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/71955/pla2g4d